Understanding mechanisms of neuropathic orofacial pain, targets of treatment, and basic pharmacology and working with informed compounding pharmacists may result in significant benefit for patients. The clinical significance of topical medications is improvement of quality of life for patients by providing a unique medication delivery system for neuropathic orofacial pain and other dental and extraoral conditions. The use of this route of administration has decreased or minimized side effects compared with other methods and is especially useful in medically compromised and elderly patients. These innovations, supported and improved by ongoing research, will augment the armamentarium of the clinician treating orofacial pain disorders.
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http://dx.doi.org/10.1016/j.cden.2013.04.011 | DOI Listing |
Front Vet Sci
December 2024
Information Systems Department, University of Haifa, Haifa, Israel.
Facial landmarks, widely studied in human affective computing, are beginning to gain interest in the animal domain. Specifically, landmark-based geometric morphometric methods have been used to objectively assess facial expressions in cats, focusing on pain recognition and the impact of breed-specific morphology on facial signaling. These methods employed a 48-landmark scheme grounded in cat facial anatomy.
View Article and Find Full Text PDFOral Surg Oral Med Oral Pathol Oral Radiol
September 2024
Department of Stomatology, School of Dentistry, Federal University of Paraná, Curitiba, Paraná, Brazil.
Unlabelled: The prevalence of temporomandibular disorder (TMD) in patients with (dentofacial deformities) DFD is high, indicating a multifaceted relationship between physical and psychosocial factors.
Objective: To identify clusters of patients with DFD based on variables related to TMD, psychological aspects, somatization, oral habits, and sleep.
Method: Ninety-two patients with DFD were evaluated before orthognathic surgery according to demographic data, facial profile, presence of painful TMD (DC/TMD), psychological aspects, oral habits, comorbidities, substance use, and sleep quality.
Photodiagnosis Photodyn Ther
December 2024
Department of Dermatology, Shenzhen People's Hospital (The Second Clinical Medical College of Jinan University; The First Affiliated Hospital of Southern University of Science and Technology), Shenzhen 518020, Guangdong, China; Candidate Branch of National Clinical Research Center for Skin Diseases, Shenzhen 518020, Guangdong, China. Electronic address:
Background: ALA-PDT has been widely used in mild to moderate acne vulgaris worldwide. However, very few studies used riboflavin-PDT to treat acne vulgaris.
Objective: To investigate the efficacy and adverse events of riboflavin-PDT to treat mild to moderate facial acne, and compare it with ALA-PDT on a non-inferiority basis.
Biochem Biophys Res Commun
December 2024
Department of Dental Anesthesiology, Osaka University Graduate School of Dentistry, 1-8 Yamadaoka, Suita, Osaka, 565-0871, Japan. Electronic address:
Pain is a major non-motor symptom of Parkinson's disease (PD). The relationship between hyperalgesia and neuropeptides originating from paraventricular nucleus (PVN) in 6-hydroxydopamine (6-OHDA) rats has already been investigated for oxytocin (OXT), but not yet for arginine vasopressin (AVP) and corticotropin-releasing hormone (CRH). The present study aimed to investigate the alterations in these neuropeptides following nociceptive stimulation in PD model rats and to examine the mechanisms of hyperalgesia.
View Article and Find Full Text PDFJ Patient Rep Outcomes
December 2024
Patient-Centered Outcomes, Adelphi Values, Bollington, Cheshire, UK.
Background: PRO measures of symptoms in clinical trials have historically utilized visual and numerical scales but verbal descriptors may make it easier for patients to clearly differentiate between response options. This study assessed content validity and meaningful change in five verbal response scales (VRSs) used to assess chronic rhinosinusitis with nasal polyp (CRSwNP) symptom severity.
Methodology: This qualitative, semi-structured interview study recruited adults from the US, Germany, and China with confirmed moderate-to-severe CRSwNP.
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