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Continuous vital sign monitoring on surgical wards: The COSMOS pilot.
J Clin Anesth
December 2024
Vice-President for Clinical and Outcomes Research; Professor of Anesthesiology, Department of Anesthesiology and Center for OutcomesResearch, University of Texas Health Science Center, Houston, TX, USA. Electronic address:
Study Objectives: Alerts for vital sign abnormalities seek to identify meaningful patient instability while limiting alarm fatigue. Optimal vital sign alarm settings for postoperative patients remain unknown, as is whether alerts lead to effective clinical responses reducing vital sign disturbances. We conducted a 2-phase pilot study to identify thresholds and delays and test the hypothesis that alerts from continuous monitoring reduce the duration of vital sign abnormalities.
View Article and Find Full Text PDFAn Interrupted Time Series Analysis of the Impact of the COVID-19 Pandemic on Routine Vaccination Uptake in Kenya.
Vaccines (Basel)
July 2024
Institute for Global Health, Centro Servizi di Ateneo Santa Chiara Lab, University of Siena, 53100 Siena, Italy.
A strategic priority of the World Health Organization's Immunization Agenda 2030 is to increase vaccination coverage and equity through reaching "zero-dose" children. Through an ecological study, we sought to quantify the impact of the COVID-19 pandemic on the coverage of the pentavalent and the measles/rubella vaccines in Kenya, without implying causality. The monthly number of doses from January 2017 to August 2022 were obtained from the Kenya Health Information System for the pentavalent and the measles/rubella vaccines.
View Article and Find Full Text PDFBackground: The COVID-19 pandemic is over but the highly immunized or naturally exposed global population still requires booster vaccinations against newly emerging SARS-CoV-2 variants. We assessed safety and immunogenicity of booster doses of COVID-19 vaccines based on three different platforms in a setting that mimics the current routine practice in Brazil.
Methods: In this phase 3 study from 14 February 2023 to 12 June 2023 we enrolled previously immunized adults to receive an additional booster dose of one of three vaccines.
Identification of Patients with Early HR+ HER2- Breast Cancer at High Risk of Recurrence.
Geburtshilfe Frauenheilkd
February 2024
University of Edinburgh Cancer Research Centre, Institute of Genetics and Cancer, Western General Hospital, Edinburgh, UK.
Article Synopsis
- Breast cancer rates have risen over the last 20 years, but survival has improved due to better detection and treatment, although some women still face relapses or metastases after initial treatment.
- About 70% of breast cancers are HR+ and HER2-, with a 20-year risk of recurrence, prompting a review of patient characteristics, biomarkers, and genomic tools for assessing high-risk cases.
- Accurate risk assessment is vital for treatment decisions, combining multiple prognostic tools and tailoring approaches to each patient’s situation to prevent over- or undertreatment.
Mpox: Keep it on the differential.
Cleve Clin J Med
September 2023
Associate Professor of Medicine, Division of Infectious Diseases, University of Pennsylvania Perelman School of Medicine, Philadelphia, PA; Corporal Michael J. Crescenz VA Medical Center, Philadelphia, PA
In its current global outbreak, mpox has exhibited several novel clinical presentations that clinicians should be aware of so they can recognize it if they see it. Although the case rate has decreased, mpox could linger at a low rate or resurface in other populations and thus should remain in the differential diagnosis in patients presenting with potential infections after intimate encounters.
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