Pathogenesis of lipogenic form of thyroid orbitopathy (TO) is presented. 172 patients with TO are presented, among them 47 males (93 orbits) and 125 females (250 orbits). Features of clinical manifestations of lipogenic form of TO are described. The results of CT of extraocular muscles (EOM) and orbital fat volume are studied in these patients and the density of EOM is assessed.

Download full-text PDF

Source

Publication Analysis

Top Keywords

lipogenic form
12
form thyroid
8
[rationale distinguishing
4
distinguishing lipogenic
4
thyroid orbitopathy]
4
orbitopathy] pathogenesis
4
pathogenesis lipogenic
4
thyroid orbitopathy
4
orbitopathy presented
4
presented 172
4

Similar Publications

Objectives: To investigate the effect of pachymic acid on brown/beige adipocyte differentiation and lipid metabolism in preadipocytes 3T3-L1 MBX.

Methods: The brown cocktail method was employed to induce 3T3-L1 MBX cells to differentiate into beige adipocytes. The impact of pachymic acid on the viability of 3T3-L1 MBX preadipocytes was evaluated using the CCK-8 assay.

View Article and Find Full Text PDF

Aberrant upregulation of fatty acid synthase (FASN), catalyzing de novo synthesis of fatty acids, occurs in various tumor types, including human hepatocellular carcinoma (HCC). Although FASN oncogenic activity seems to reside in its pro-lipogenic function, cumulating evidence suggests that FASN's tumor-supporting role might also be metabolic-independent. : In the present study, we show that FASN inactivation by specific small interfering RNA (siRNA) promoted the downregulation of the S-phase kinase associated-protein kinase 2 (SKP2) and the consequent induction of p27 in HCC cell lines.

View Article and Find Full Text PDF

Steroid-induced osteonecrosis of the femoral head (SONFH) is a prevalent form of osteonecrosis in young individuals. More efficacious clinical strategies must be used to prevent and treat this condition. One of the mechanisms through which SONFH operates is the disruption of normal differentiation in bone marrow adipocytes and osteoblasts due to prolonged and extensive use of glucocorticoids (GCs).

View Article and Find Full Text PDF

Regulation of hepatic lipogenesis by asymmetric arginine methylation.

Metabolism

August 2024

Division of Life Sciences, Korea University, Seoul 02841, Republic of Korea. Electronic address:

Article Synopsis
  • The study investigates how PRMT6, a protein linked to various metabolic processes, interacts with and regulates LXR alpha, which is important for hepatic lipogenesis and lipid metabolism.
  • Researchers found that PRMT6 enhances the promoter activity of SREBP-1c by binding to LXR alpha and methylating it, leading to increased lipogenesis in the liver.
  • The findings suggest that PRMT6 plays a significant role in controlling lipid accumulation in the liver, which could have implications for conditions like non-alcoholic fatty liver disease (NAFLD).
View Article and Find Full Text PDF

Ferroptosis is a form of regulated cell death that is induced by inhibiting glutathione peroxidase 4 (GPX4), which eliminates lipid peroxidation. Ferroptosis induction is influenced by the cell environment. However, the cellular states altering ferroptosis susceptibility remain largely unknown.

View Article and Find Full Text PDF

Want AI Summaries of new PubMed Abstracts delivered to your In-box?

Enter search terms and have AI summaries delivered each week - change queries or unsubscribe any time!