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Rapid human oogonia-like cell specification via transcription factor-directed differentiation.
EMBO Rep
January 2025
Department of Biomedical Engineering, Duke University, Durham, NC, USA.
The generation of germline cells from human induced pluripotent stem cells (hiPSCs) represents a milestone toward in vitro gametogenesis. Methods to recapitulate germline development beyond primordial germ cells in vitro have relied on long-term cell culture, such as 3-dimensional organoid co-culture for ~four months. Using a pipeline with highly parallelized screening, this study identifies combinations of TFs that directly and rapidly convert hiPSCs to induced oogonia-like cells (iOLCs).
View Article and Find Full Text PDFA thin film optoelectronic photodetector of spherical and linear resonators via one-pot synthesis of Bi(III) oxide/polypyrrole nanocomposite.
Sci Rep
January 2025
Department of Physics, College of Science, Princess Nourah bint Abdulrahman University, P.O. Box 84428, Riyadh, 11671, Saudi Arabia.
We report the fabrication and characterization of a Bi(III) oxide/polypyrrole (BiO/Ppy) nanocomposite thin film optoelectronic photodetector synthesized by a simple one-pot method. The nanocomposite consists of spherical BiO nanoparticles embedded in a Ppy matrix, forming a porous structure with a high surface area. The XRD analysis reveals that the BiO nanoparticles have a poly-crystalline nature with a crystal size of 40 nm and an optical bandgap of 2.
View Article and Find Full Text PDFDevelopment of a phosphoaminopyrazine-loaded cellulose nanoparticle drug delivery system for targeted treatment of triple-negative breast cancer.
Int J Biol Macromol
January 2025
Department of Chemistry, Faculty of Science, Tarbiat Modares University, Tehran, Iran.
This study explores the development of a sustainable drug delivery system using cellulose nanoparticles (CNPs) derived from potato pulp for the controlled release of phosphoaminopyrazine (PAP), a promising anticancer agent. CNPs were synthesized via nanoprecipitation, and PAP was loaded through in-situ nanoprecipitation, achieving a high loading efficiency of 79.2 %.
View Article and Find Full Text PDFExploring biomass derived microcrystalline cellulose from the waste aquatic plant Pistia stratiotes: A comprehensive characterization for polymer composite reinforcement.
Int J Biol Macromol
January 2025
School of Chemical Engineering, Yeungnam University, 280 Daehak-Ro, Gyeongsan, Gyeongbuk 38541, Republic of Korea. Electronic address:
The creation of polymer composites with better performance is a crucial thing. The cellulosic filler material gain popularity in polymer composites. In this study, aquatic plant Pistia stratiote leaves were used as a raw material for cellulose extraction.
View Article and Find Full Text PDFChanges in the intestinal microbiota induced by the postnatal environment and their association with hypertension.
Pharmacol Res
January 2025
Laboratory of Vascular Physiology, Department of Physiology and Biophysics, Institute of Biomedical Science, University of Sao Paulo, Sao Paulo, Brazil. Electronic address:
It has been established that cross-fostering impacts the development of hypertension in spontaneously hypertensive rats (SHR). However, the ability of the cross-fostering protocol to shape gut microbiota profile in SHR and impact hypertension is not known. In this sense, the current study explored the influence of normotensive and hypertensive postnatal environments on the intestinal microbiota structure, composition, and functional capacity of SHR and Wistar rats.
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