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Re-identification and characterization of grass carp TLR20.
Fish Shellfish Immunol Rep
December 2023
Hubei Hongshan Laboratory, College of Fisheries, Huazhong Agricultural University, Wuhan 430070, China.
Toll-like receptors (TLRs) play a crucial role in the recognition of microbial-associated molecular patterns in the innate immune system. Fish TLRs have undergone significant gene expansion to adapt to complex aquatic environments. Among them, TLR20 from the TLR11 family actively responds to viral and bacterial invasions.
View Article and Find Full Text PDFReal-time Protection of Genomic Data Sharing in Beacon Services.
AMIA Jt Summits Transl Sci Proc
May 2018
School of Informatics, Computing and Engineering, Indiana University, Bloomington, IN, USA.
The acquisition of human genomic sequences is of increasing convenience and reduced expense. The sharing of these data is critical for biomedical researchers to study genomic loci or variants that are potentially associated with human diseases. However, sharing genomic data broadly is impeded by privacy concerns.
View Article and Find Full Text PDFAddressing Beacon re-identification attacks: quantification and mitigation of privacy risks.
J Am Med Inform Assoc
July 2017
School of Computer and Communication Sciences, École Polytechnique Fédérale de Lausanne, Lausanne, Switzerland.
The Global Alliance for Genomics and Health (GA4GH) created the Beacon Project as a means of testing the willingness of data holders to share genetic data in the simplest technical context-a query for the presence of a specified nucleotide at a given position within a chromosome. Each participating site (or "beacon") is responsible for assuring that genomic data are exposed through the Beacon service only with the permission of the individual to whom the data pertains and in accordance with the GA4GH policy and standards.While recognizing the inference risks associated with large-scale data aggregation, and the fact that some beacons contain sensitive phenotypic associations that increase privacy risk, the GA4GH adjudged the risk of re-identification based on the binary yes/no allele-presence query responses as acceptable.
View Article and Find Full Text PDFPrivacy Risks from Genomic Data-Sharing Beacons.
Am J Hum Genet
November 2015
Department of Genetics, Stanford University, Stanford, CA 94305, USA. Electronic address:
The human genetics community needs robust protocols that enable secure sharing of genomic data from participants in genetic research. Beacons are web servers that answer allele-presence queries--such as "Do you have a genome that has a specific nucleotide (e.g.
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