AI Article Synopsis
- The study aimed to explore the relationship between the NFKB1 -94 ins/del ATTG (rs28720239) polymorphism and colorectal cancer (CRC) risk among Malaysians by analyzing allele and genotype frequencies.
- Researchers analyzed DNA from 474 individuals, including 237 CRC patients and 237 cancer-free controls, using PCR-RFLP and confirmed results with DNA sequencing.
- Findings indicated that the variant genotype was more common in CRC patients (14.8%) compared to controls (6.8%) and was associated with a significantly higher risk of CRC (OR=2.42).
Article Abstract
Objective: To investigate the allele and genotype frequencies of NFKB1 -94 ins/del ATTG (rs28720239) polymorphism and to evaluate the association between the polymorphism and colorectal cancer (CRC) risk in Malaysian population.
Methods: Genomic DNA was extracted from the peripheral blood samples of 474 study subjects, which consisted of 237 histopathologically confirmed CRC patients and an equal number of cancer-free controls. The NFKB1 -94 ins/del ATTG (rs28720239) polymorphism was genotyped using polymerase chain reaction-restriction fragment length polymorphism (PCR-RFLP) method and confirmed by DNA sequencing. The association between the polymorphic genotypes and CRC risk was evaluated by deriving odds ratios (ORs) and 95% confidence intervals (CIs) using unconditional logistic regression analysis.
Results: The frequencies of wildtype (del/del), heterozygous (del/ins) and variant (ins/ins) genotypes in CRC patients were 31.7%, 53.6% and 14.8%, respectively, while those in cancer-free controls were 35.0%, 58.2% and 6.8%, respectively. The frequency of the variant genotype was significantly higher in cases compared to controls (P<0.01). Evaluation of the risk association of the polymorphic genotypes revealed that the variant genotype could contribute to a significantly increased risk of CRC (OR=2.42, 95% CI=1.24-4.73, P<0.01).
Conclusions: The variant allele of NFKB1 -94 ins/del ATTG (rs28362491) polymorphism is associated with higher risk of sporadic CRC in Malaysian population.
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| http://dx.doi.org/10.1016/j.canep.2013.05.007 | DOI Listing |
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