The natural history of congenitally corrected transposition of the great arteries is of clinical/surgical importance once the fetus is born without heart block or signs of heart failure. Without significant tricuspid valve malformation, associated defects such as ventricular septal defect and left ventricular outflow obstruction can be repaired surgically. The mortality and long-term outcome appear to be linked strongly with the severity of tricuspid valve regurgitation. Some patients with an intact ventricular septum and no right ventricular dysfunction will live long lives without detection, and some women will successfully complete pregnancy.
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http://dx.doi.org/10.1177/2150135110387620 | DOI Listing |
Sci Rep
December 2024
Department of Biology, Queen's University, Kingston, ON, Canada.
Genetic diversity can influence fitness components such as survival and reproductive success. Yet the association between genetic diversity and fitness based on neutral loci is sometime very weak and inconsistent, with relationships varying among taxa due to confounding effects of population demography and life history. Fitness-diversity relationships are likely to be stronger and more consistent for genes known to influence phenotypic traits, such as immunity-related genes, and may also depend on the genetic differences between breeding partners.
View Article and Find Full Text PDFNat Commun
December 2024
Anthropology Department, University of California Santa Cruz, Santa Cruz, CA, USA.
Strontium isotope (Sr/Sr) analysis with reference to strontium isotope landscapes (Sr isoscapes) allows reconstructing mobility and migration in archaeology, ecology, and forensics. However, despite the vast potential of research involving Sr/Sr analysis particularly in Africa, Sr isoscapes remain unavailable for the largest parts of the continent. Here, we measure the Sr/Sr ratios in 778 environmental samples from 24 African countries and combine this data with published data to model a bioavailable Sr isoscape for sub-Saharan Africa using random forest regression.
View Article and Find Full Text PDFNat Commun
December 2024
KoBold Metals, Berkeley, CA, USA.
Plate tectonics is a unique feature of Earth, but its proposed time of initiation is still controversial, with published estimates ranging from ca. 4.2 to 0.
View Article and Find Full Text PDFEcol Lett
January 2025
Department of Anthropology, University of Utah, Salt Lake City, Utah, USA.
Modern African ungulates navigate seasonal variation in resource availability through diet-switching (primarily mixed-feeders) and/or migrating (primarily grass grazers). These ecological generalisations are well-documented today, but the extent to which they apply to the non-analog ecosystems of the Pleistocene are unclear. Drawing from serially-sampled stable isotope measurements from 18 Kenyan large herbivore species from the Last Glacial Period (LGP), we evaluate how diet, diet-switching, and migration compare to observations from present-day settings.
View Article and Find Full Text PDFSyst Biol
December 2024
Department of Plant Pathology, Nanjing Agricultural University, Nanjing 210095, China.
The phylum Nematoda represents one of the most cosmopolitan and abundant metazoan groups on Earth. In this study, we reconstructed the phylogenomic tree for phylum Nematoda. A total of 60 genomes, belonging to eight nematode orders, were newly sequenced, providing the first low-coverage genomes for the orders Dorylaimida, Mononchida, Monhysterida, Chromadorida, Triplonchida, and Enoplida.
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