Objective: Serological studies on the relationship between adenovirus 36 (Ad36) and an increased risk of obesity development have shown conflicting results. We reviewed the published studies and carried out a meta-analysis to explore this relationship.
Methods: PubMed was searched until December 2012 for the relative references with sufficient information to estimate odds ratios (ORs) and 95% confidence intervals (CIs). A total of 11 case-control studies, including 2508 obese subjects and 3005 controls, were selected.
Results: Compared with nonobese controls, Ad36 infection significantly increased the obesity risk by a pooled OR of 1.60 (95% CI = 1.14-2.25; P < 0.01). Meta-regression showed that the types of subject and obesity assessments were potential risk factors. In the subgroup analysis, a significantly increased risk was found in children (OR = 1.95; 95% CI = 1.34-2.85; z = 3.45; P < 0.01) and those with an obesity assessment of BMI ≥ 30 kg/cm2 (OR = 1.89; 95% CI = 1.15-3.10; P < 0.05).
Conclusions: Ad36 infection is associated with an increased risk of obesity development. To our knowledge, this is the first report to reveal the significant relationship in children with a serological data analysis.
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