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Thyrotoxic periodic paralysis in a Caucasian man without identifiable genetic predisposition: a case report.
Thyroid Res
May 2023
Department of Endocrinology and Nephrology, Nordsjællands Hospital, Dyrehavevej 29, DK-3400, Hillerød, Denmark.
Article Synopsis
- Thyrotoxic periodic paralysis (TPP) is a rare disease causing muscle paralysis and low potassium levels, often rapidly reversible with potassium treatment.
- A 19-year-old man presented with paralysis and symptoms related to hyperthyroidism, leading to a diagnosis of TPP with critical lab results indicating severe potassium deficiency and abnormal thyroid hormone levels.
- He was treated successfully with potassium and medication for Graves' disease, eventually being discharged with normal potassium levels and ongoing outpatient care.
Thyrotoxic Periodic Paralysis With Severe Hypokalemia Precipitated by Acute Alcohol Intoxication in a Patient With Graves' Disease.
Cureus
February 2023
Department of Endocrinology, Diabetes and Metabolism, HealthPartners, Minneapolis, USA.
We present a case of a 29-year-old male who presented with thyrotoxic periodic paralysis (TPP) precipitated by acute alcohol intoxication. TPP is an endocrine emergency that presents with an episode of acute flaccid paralysis with hypokalemia in the setting of thyrotoxicosis. Individuals who present with TPP are thought to have an underlying genetic predisposition.
View Article and Find Full Text PDF[Orbital myositis, a cause of pediatric painful ophthalmoplegia].
Rev Chil Pediatr
December 2020
Departamento de Pediatría, Facultad de Medicina, Universidad de Antioquia, Medellín, Colombia.
Introduction: Orbital myositis (OM) is a serious inflammation of extraocular muscles with unknown etiology. Pe diatric presentation is rare and often affects more than one individual in a family, suggesting a genetic predisposition.
Objective: To describe a pediatric case of orbital myositis, its clinical characteristics, and the usefulness of MRI for confirming the diagnosis.
Thyrotoxic Muscle Paralysis as a Rare Cause of Reversible Muscle Weakness: A Case Report.
Cureus
September 2020
Endocrinology, Diabetes and Metabolism, Northwell Health, New York, USA.
Thyrotoxic periodic paralysis is a clinical condition characterized by muscle weakness in patients with underlying hyperthyroidism. It is usually more commonly seen in patients of Asian origin and has a predisposition for the male population (unlike other thyroid disorders which commonly affect the female population). Findings are more overt in patients who have subclinical hyperthyroidism and there is a risk of them remaining untreated.
View Article and Find Full Text PDFGenome-wide meta-analysis reveals novel susceptibility loci for thyrotoxic periodic paralysis.
Eur J Endocrinol
December 2020
Department of Medicine, Li Ka Shing Faculty of Medicine, The University of Hong Kong, Hong Kong.
Article Synopsis
- The study investigates thyrotoxic periodic paralysis (TPP), a serious complication of hyperthyroidism, by analyzing genetic data from 319 TPP patients and 3,516 healthy individuals to identify potential genetic risk factors.
- Through the analysis of over 7 million genetic variants, researchers found 260 significant variants linked to TPP, including two novel risk loci near the TRIM2 and AC140912.1 genes, which were associated with changes in gene expression.
- The findings suggest that common genetic variations may play a role in TPP, potentially leading to milder symptoms compared to rare mutations previously associated with more severe muscle paralysis disorders.
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