The hemangioblast, a bipotent progenitor that generates both endothelial cells (EC) and blood cells (BC) in the blood islands (BI) of the yolk sac (YS) has been a core notion of developmental hematology since the early 20th century. However, its actual presence has not been directly addressed for long. At the very end of the 20th century, the hemangioblast was revisited as a result of the development of new technologies that enable detection of such bipotent precursors in vitro. Such studies provided evidence for the presence of bipotent precursors for EC and BC. On the other hand, subsequent studies analyzing the processes occurring within BI strongly argued against the notion of hemanigioblasts and suggest that the hemangioblast is an in vitro artefact. In this article, I overview the history of the study of the hemangioblast and try to explain why hemangioblast that can be defined in vitro cannot be detected in BI.
Download full-text PDF |
Source |
|---|---|
| http://dx.doi.org/10.1002/wdev.38 | DOI Listing |
Publication Analysis
Top Keywords
Similar Publications
Bone morphogenetic protein 4 induces hematopoietic stem cell development from murine hemogenic endothelial cells in culture.
Stem Cell Reports
December 2024
Department of Cell Differentiation, Institute of Molecular Embryology and Genetics, Kumamoto University, Kumamoto, Japan. Electronic address:
Hematopoietic stem cells (HSCs) develop from hemogenic endothelial cells (HECs) during mouse embryogenesis. Understanding the signaling molecules required for HSC development is crucial for the in vitro derivation of HSCs. We previously induced HSCs from embryonic HECs, isolated at embryonic day 10.
View Article and Find Full Text PDFEfficient generation of human NOTCH ligand-expressing haemogenic endothelial cells as infrastructure for in vitro haematopoiesis and lymphopoiesis.
Nat Commun
September 2024
Murdoch Children's Research Institute, The Royal Children's Hospital, Parkville, VIC, Australia.
Article Synopsis
- The study reveals a method to create human haemogenic DLL4+ arterial endothelial cells (AECs) from pluripotent stem cells, essential for forming blood cells during embryonic development.* -
- Using single-cell RNA sequencing, researchers tracked the development of blood cell types in human embryos, identifying key pre-haematopoietic stem cell genes along the way.* -
- The research shows that IL7 influences the decision between T cells and innate lymphoid cells and establishes a pathway for RAG1+ lymphoid precursors to develop into natural killer cells, offering insights into blood system development.*
Tropomyosin 1 deficiency facilitates cell state transitions and enhances hemogenic endothelial cell specification during hematopoiesis.
Stem Cell Reports
September 2024
Division of Neonatology, Children's Hospital of Philadelphia, Philadelphia, PA, USA; Department of Pediatrics, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA, USA. Electronic address:
Article Synopsis
- - Tropomyosin 1 (TPM1) is linked to variations in human blood traits and influences actin-related cell processes, but its role in blood cell formation (hematopoiesis) is not fully understood.
- - Research using gene-edited stem cells showed that knocking out TPM1 promoted the development of specific blood-forming cells and activated important signaling pathways.
- - Further studies with a mouse model indicated that lacking TPM1 increased the formation of endothelial cells during early development, highlighting its significant role in regulating blood cell development.
Transition of signal requirement in hematopoietic stem cell development from hemogenic endothelial cells.
Proc Natl Acad Sci U S A
July 2024
Department of Cell Differentiation, Institute of Molecular Embryology and Genetics, Kumamoto University, Kumamoto 860-0811, Japan.
Hematopoietic stem cells (HSCs) develop from hemogenic endothelial cells (HECs) in vivo during mouse embryogenesis. When cultured in vitro, cells from the embryo phenotypically defined as pre-HSC-I and pre-HSC-II have the potential to differentiate into HSCs. However, minimal factors required for HSC induction from HECs have not yet been determined.
View Article and Find Full Text PDFCD32 captures committed haemogenic endothelial cells during human embryonic development.
Nat Cell Biol
May 2024
San Raffaele Telethon Institute for Gene Therapy, IRCCS San Raffaele Scientific Institute, Milan, Italy.
During embryonic development, blood cells emerge from specialized endothelial cells, named haemogenic endothelial cells (HECs). As HECs are rare and only transiently found in early developing embryos, it remains difficult to distinguish them from endothelial cells. Here we performed transcriptomic analysis of 28- to 32-day human embryos and observed that the expression of Fc receptor CD32 (FCGR2B) is highly enriched in the endothelial cell population that contains HECs.
View Article and Find Full Text PDFWant AI Summaries of new PubMed Abstracts delivered to your In-box?
Enter search terms and have AI summaries delivered each week - change queries or unsubscribe any time!