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EXPRESS: In Silico Exploration of Bioactive Secondary Metabolites with Anesthetic Effects on Sodium Channels Nav 1.7, 1.8, and 1.9 in Painful Human Dental Pulp.
Mol Pain
March 2025
Department of Prosthodontics, Faculty of Stomatology, Yerevan State Medical University after Mkhitar Heratsi, Str. Koryun 2, Yerevan 0025, Armenia.
Aim: To investigate the efficacy of medicinal plant bioactive secondary metabolites as inhibitors of voltage-gated sodium channels (Nav1.7, Nav1.8, and Nav1.
View Article and Find Full Text PDFA critical review of the ecotoxic effects of microplastics on aquatic, soil and atmospheric ecosystems and current research challenges.
Environ Res
March 2025
Key Laboratory of Environmental Medicine and Engineering, Ministry of Education, School of Public Health, Southeast University, Nanjing 210009, China.
The extensive use of plastics has brought unparalleled convenience to human social development. However, this has also led to severe environmental and health challenges, with microplastic (MP) pollution emerging as one of the most pressing issues. As ubiquitous environmental pollutants, MPs persist in ecosystems and pose potential risks to both ecological and human health.
View Article and Find Full Text PDFInsights into therapeutic potential and practical applications of natural toxins from poisonous mushrooms.
Hum Exp Toxicol
March 2025
Food Science and Technology Program, Department of Life Sciences, BNU-HKBU United International College, Zhuhai, China.
IntroductionMushrooms, belonging to the phyla Ascomycota and Basidiomycota, comprise approximately 14,000 known species, among which a small fraction are toxic. While toxic mushrooms are primarily associated with adverse health effects, recent research highlights their potential as sources of bioactive compounds with promising therapeutic applications.MethodsA systematic review was conducted using four major electronic databases: Web of Science, Google Scholar, PubMed, and ScienceDirect.
View Article and Find Full Text PDFFrom Nature to Emergency: Cardiac Complications Following the Consumption of Unwashed Fruit.
Cureus
February 2025
Cardiology, Hamad Medical Corporation, Doha, QAT.
(Sidr) is widely used for its medicinal and nutritional properties, with documented pharmacological effects such as antidiabetic, sedative, and antihypertensive activities. However, its consumption, especially in unregulated settings, can pose significant health risks due to potential toxicity and contamination with pesticides. We report the case of a 25-year-old male who presented with severe abdominal pain radiating to the chest, profound bradycardia (heart rate in the 20s), hypotension (systolic blood pressure in the 50s), and autonomic symptoms after ingesting unwashed fruit.
View Article and Find Full Text PDFAssessment of the biosafety profile of on myoblasts and on chorioallantoic membrane.
World J Cardiol
February 2025
Department of Pharmaceutical Technology, "Victor Babes" University of Medicine and Pharmacy, Timisoara 300041, Romania.
Background: Cardiovascular diseases are the first cause of death in the world. Ischemic heart disease is the main cause of heart failure. New approaches are continuously sought to identify better therapeutic success.
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