Retapamulin and six other antimicrobial agents were evaluated against 155 methicillin-resistant (MRSA) isolates, including strains resistant to vancomycin, linezolid, daptomycin, and mupirocin by microdilution tests. Time-kill assays were performed against representative MRSA, vancomycin-intermediate (VISA), and vancomycin-resistant (VRSA) isolates. Retapamulin and mupirocin demonstrated MICs of 0.12 μg/ml and 8 μg/ml, respectively, with resistance seen in 2.6% and 10% of isolates, respectively. Retapamulin maintained good activity against 94% (15/16) of mupirocin-resistant isolates.
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|---|---|
| http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3754297 | PMC |
| http://dx.doi.org/10.1128/AAC.00282-13 | DOI Listing |
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