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The total synthesis of hypodematine. | LitMetric

The total synthesis of hypodematine.

J Asian Nat Prod Res

a State Key Laboratory of Bioactive Substance and Function of Natural Medicines, Institute of Materia Medica, Peking Union Medical College and Chinese Academy of Medical Sciences, Beijing , 100050 , China.

Published: November 2013

Hypodematine, isolated from Hypodematium sinense Iwatsuki as an alkaloid with a new skeleton, was synthesized via nine reaction steps, in which the synthesis of 2-aryl-1-benzazocines via Beckmann rearrangement of 5H-benzocyclohepten-5-one oxime mesylate in dry toluene is discussed.

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Source
http://dx.doi.org/10.1080/10286020.2013.805749DOI Listing

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