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miR-124 controls male reproductive success in Drosophila. | LitMetric

miR-124 controls male reproductive success in Drosophila.

Elife

Institute for Molecular and Cell Biology , Singapore , Singapore ; Department of Biological Sciences , National University of Singapore, Singapore , Singapore.

Published: June 2013

AI Article Synopsis

  • Many social behaviors in organisms are influenced by sex-specific pheromones, which are regulated by key transcription factors like doublesex and fruitless.
  • Mutant males lacking the miR-124 microRNA displayed abnormal male-male courtship and struggled to reproduce with females, while females preferred typical males over these mutants.
  • The study identified the splicing factor transformer as a crucial target of miR-124, indicating that miR-124 plays a role in maintaining proper male pheromone production and sexual behavior by preventing female transformer expression.

Article Abstract

Many aspects of social behavior are controlled by sex-specific pheromones. Gender-appropriate production of the sexually dimorphic transcription factors doublesex and fruitless controls sexual differentiation and sexual behavior. miR-124 mutant males exhibited increased male-male courtship and reduced reproductive success with females. Females showed a strong preference for wild-type males over miR-124 mutant males when given a choice of mates. These effects were traced to aberrant pheromone production. We identified the sex-specific splicing factor transformer as a functionally significant target of miR-124 in this context, suggesting a role for miR-124 in the control of male sexual differentiation and behavior, by limiting inappropriate expression of the female form of transformer. miR-124 is required to ensure fidelity of gender-appropriate pheromone production in males. Use of a microRNA provides a secondary means of controlling the cascade of sex-specific splicing events that controls sexual differentiation in Drosophila. DOI:http://dx.doi.org/10.7554/eLife.00640.001.

Download full-text PDF

Source
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3679528PMC
http://dx.doi.org/10.7554/eLife.00640DOI Listing

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