Download full-text PDF |
Source |
|---|---|
| http://dx.doi.org/10.1002/anie.201303544 | DOI Listing |
Publication Analysis
Top Keywords
Similar Publications
Enrichable Protein Footprinting for Structural Proteomics.
J Am Soc Mass Spectrom
December 2024
Center for Genomic Science Innovation, University of Wisconsin Madison, Madison, Wisconsin 53706, United States.
Protein footprinting is a useful method for studying protein higher order structure and conformational changes induced by interactions with various ligands via addition of covalent modifications onto the protein. Compared to other methods that provide single amino acid-level structural resolution, such as cryo-EM, X-ray diffraction, and NMR, mass spectrometry (MS)-based methods can be advantageous as they require lower protein amounts and purity. As with other MS-based proteomic methods, such as post-translational modification analysis, enrichment techniques have proven necessary for both optimal sensitivity and sequence coverage when analyzing highly complex proteomes.
View Article and Find Full Text PDFAu(PPh)Cl/AgOTf/TsOH-Catalyzed Cascade Reaction between 1-(2-Hydroxyphenyl)-propargyl Alcohols and β-Oxoketones (Amides, Acid): Diastereoselective Construction of -3a,8a-Dihydrofuro[2,3-]benzofuran Framework.
J Org Chem
December 2024
Key Laboratory of Chemical Biology and Traditional Chinese Medicine Research (Ministry of Education of China), Hunan Normal University, Changsha 410081, China.
In the Au(PPh)Cl/AgOTf/TsOH/MeCN/N/25 °C system, diastereoselective synthesis of -3a,8a-dihydrofuro[2,3-]benzofuran derivatives with a substituent at the 8a-position has been achieved by using 1-(2-hydroxyphenyl)-3-arylprop-2-yn-1-ols and β-oxoketones (amides, acid) as starting materials. The studies revealed that the acidity of methylene in substrates plays a key role in the differential reactions. A stronger acidity of the methylene is favorable in the desired conversion.
View Article and Find Full Text PDFEvaluating the halogen bonding strength of a iodoloisoxazolium(III) salt.
Beilstein J Org Chem
September 2024
Fakultät für Chemie und Biochemie, Ruhr-Universität Bochum, Universitätsstraße 150, 44801 Bochum, Germany.
Diaryliodonium(III) salts have been established as powerful halogen-bond donors in recent years. Herein, a new structural motif for this compound class was developed: iodoloisoxazolium salts, bearing a cyclic five-membered iodolium core fused with an isoxazole ring. A derivative of this class was synthesized and investigated in the solid state by X-ray crystallography.
View Article and Find Full Text PDFIntegrating 3,4-Dihydro-2-1,4-oxazine into Peptides as a Modification: Silver Triflate-Catalyzed Cyclization of -Propargyl -Sulfonyl Amino Alcohols for SPPS Applications.
Org Lett
September 2024
Organic Chemistry Division, CSIR-National Chemical Laboratory, Dr. Homi Bhabha Road, Pune-411008, India.
We present a methodology yielding 3,4-dihydro-2-1,4-oxazine by cyclization of -propargyl -sulfonyl amino alcohols using silver triflate as a catalyst at ambient temperature. Additionally, we showcase the applicability of this methodology in solid phase peptide synthesis (SPPS) to introduce the oxazine heterocyclic ring into short peptides containing serine and threonine. Notably, Rink amide resin supported the on-resin formation of 3,4-dihydro-2-1,4-oxazine, while 2-CTC resin facilitated the oxazine formation in a one-pot process involving peptide cleavage, deprotection, and subsequent C-O ring formation, thus offering a versatile method for the late-stage modification of peptides.
View Article and Find Full Text PDFCatalytic Enantioselective Propargylation of Pyrazolones by Amide-Based Phase-Transfer Catalysts.
Org Lett
September 2024
School of Pharmacy, Xinxiang Medical University, Xinxiang, Henan 453003, P.R. China.
In this paper, we developed a highly enantioselective alkylation of 4-substituted pyrazolones catalyzed by phase-transfer catalysis. Cheap halohydrocarbons were employed as electrophilic alkylationg agents, and propargyl, allyl, and benzyl products with all-carbon quaternary stereocenters were afforded with excellent enantioselectivities and good yields. We found that the unique structures of the catalyst (hydrogen bond donors of the C-9 hydroxyl group and amide group, the triphenyl at the -position) were important for good enantioselectivity.
View Article and Find Full Text PDFWant AI Summaries of new PubMed Abstracts delivered to your In-box?
Enter search terms and have AI summaries delivered each week - change queries or unsubscribe any time!