AI Article Synopsis
- Drug-induced lesions of the oral mucosa can occur as side effects from commonly prescribed medications, like the ACE inhibitor lisinopril used for hypertension.
- A female patient developed oral blisters and ulcers three weeks after starting lisinopril, initially leading to a diagnosis of drug-induced pemphigus but later showed no autoantibodies typical for the condition.
- After discontinuing lisinopril, the patient's symptoms completely resolved within a month, prompting a discussion about the appropriateness of labeling such drug reactions as pemphigus without meeting specific immunopathological criteria.
Article Abstract
Drug-induced lesions of oral mucosa are well-established side effect of different commonly used drugs. A female patient under treatment for hypertension with an angiotensin-converting enzyme inhibitor (ACE inhibitor), lisinopril, developed blisters and ulcerations on oral mucosa 3 weeks after lisinopril intake. Due to clinical finding drug-induced pemphigus was considered. However, direct and indirect immunofluorescence anal-ysis revealed no autoantibodies that are commonly present in pemphigus while histological study suggested allergic reaction. Lisinopril was discontinued from further therapy and after a month after her first arrival patient has experienced complete remission of the disease. This case raises the question, whether the term pemphigus in drug-induced reactions could be used when immunopathological criteria for pemphigus are not fulfilled.
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| http://dx.doi.org/10.1007/s00508-013-0382-7 | DOI Listing |
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