AI Article Synopsis
- Histoplasmosis is a fungal infection found largely in the Americas, and this report describes a male patient with rare oral and skin lesions caused by it.
- The patient was also discovered to have advanced HIV infection, evidenced by a very low CD4+ cell count.
- Treatment included amphotericin B, followed by itraconazole and antiretroviral therapy, resulting in apparent recovery, highlighting the importance of testing for HIV in patients with histoplasmosis since it can indicate serious underlying conditions.
Article Abstract
Histoplasmosis is a systemic mycosis endemic in extensive areas of the Americas. The authors report on an urban adult male patient with uncommon oral-cutaneous lesions proven to be histoplasmosis. Additional investigation revealed unnoticed HIV infection with CD4+ cell count of 7/mm3. The treatment was performed with amphotericin B, a 2065 mg total dose followed by itraconazole 200mg/daily plus antiretroviral therapy with apparent cure. Histoplasmosis is an AIDS-defining opportunistic disease process; therefore, its clinical diagnosis must drive full laboratory investigation looking for unnoted HIV-infection.
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Source |
|---|---|
| http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3754376 | PMC |
| http://dx.doi.org/10.1590/abd1806-4841.20131812 | DOI Listing |
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