Survivin is a member of the inhibitor of apoptosis (IAP) family and has multifunctional properties that include aspects of proliferation, invasion and cell survival control. Survivin is a promising candidate for targeted cancer therapy as its expression is associated with poor clinical outcome, more aggressive clinico-pathologic features, and resistance to radiation and chemotherapy. In the present review the different properties of the Survivin splice variants are discussed and their activities correlated with different aspects of cancer cell biology, to include subcellular location. Special emphasis is placed on our current understanding of these Survivin splice variants influence on each other and on the phenotypic responses to therapy that they may control.
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| http://dx.doi.org/10.1016/j.canlet.2013.06.007 | DOI Listing |
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Introduction: Although neuroendocrine neoplasms (NENs) have a good prognosis, distant metastasis remains a crucial prognostic factor. Survivin, a tumor-associated antigen, is overexpressed in several solid tumors, indicating poor prognosis. We aimed to evaluate the clinical significance and role of survivin as a therapeutic target for NEN.
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Institute of Neuroanatomy, RWTH University Hospital Aachen, Aachen, Germany.
Glioblastoma multiforme (GBM) presents a significant challenge in neuro-oncology due to its aggressive behavior and self-renewal capacity. Circular RNAs (circRNAs), a subset of non-coding RNAs (ncRNAs) generated through mRNA back-splicing, are gaining attention as potential targets for GBM research. In our study, we sought to explore the functional role of circMMP9 (circular form of matrix metalloproteinase-9) as a promising therapeutic target for GBM through bioinformatic predictions and human data analysis.
View Article and Find Full Text PDFInhibition of survivin by 2'--methyl phosphorothioate-modified steric-blocking antisense oligonucleotides.
RSC Adv
April 2024
Centre for Molecular Medicine and Innovative Therapeutics, Health Futures Institute, Murdoch University Murdoch 6150 Australia
Article Synopsis
- Chemically modified antisense oligonucleotides (ASOs) have been proven effective in treating various diseases, with ten approved ASO drugs currently on the market, mainly for conditions other than cancer.
- Researchers have developed steric-blocking ASOs that specifically target a known oncogene, initially screening seven candidates in HepG2 cells and identifying ASO-2 and ASO-7 as the most effective in reducing mRNA levels.
- Further testing demonstrated that ASO-7 not only inhibited mRNA expression in a dose-dependent manner but also significantly reduced survivin protein levels, suggesting its potential as a therapeutic BIRC5 inhibitor.
Low Expression of BIRC5-206 Promotes Cancer Progression in Nasopharyngeal Carcinoma via Enhancing Expression of Stem Cell Markers.
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Central Laboratory, Hainan General Hospital, Hainan Hospital Affiliated to The Hainan Medical College, Hainan Provincial Key Laboratory of Cell and Molecular Genetic Translational Medicine, Haikou, Hainan Province, China
Objective: Survivin is highly expressed in various malignant tumor cells and positively related to poor prognosis and drug resistance. This study aimed to explore the role of non-coding splice variant of Survivin, BIRC5-206 (ENST00000589892.1) in the progression of nasopharyngeal carcinoma (NPC), a malignant tumor that highly occurs in the southern region of China.
View Article and Find Full Text PDFPLK1 and AURKB phosphorylate survivin differentially to affect proliferation in racially distinct triple-negative breast cancer.
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Department of Biology, Georgia State University, Atlanta, GA, 30303, USA.
Protein diversity due to alternative mRNA splicing or post-translational modifications (PTMs) plays a vital role in various cellular functions. The mitotic kinases polo-like kinase 1 (PLK1) and Aurora B (AURKB) phosphorylate survivin, an inhibitor of apoptosis (IAP) family member, thereby regulating cell proliferation. PLK1, AURKB, and survivin are overexpressed in triple-negative breast cancer (TNBC), an aggressive breast cancer subtype.
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