Primary hypoparathyroidism is a disease in which the parathyroid glands decrease or cease secretion of parathyroid hormone, leading to clinically significant hypocalcemia. Although considered a rare condition, hypoparathyroidism seems to occur much more frequently than reported. In most cases, hypoparathyroidism remains a complication of neck surgery. However, many other pathologic conditions may be implicated in its pathogenesis. Here we present a case of a patient in whom hypoparathyroidism developed as a complication of hereditary hemochromatosis and was followed by hypogonadism, representing an atypical clinical manifestation of this disorder. In the article, we describe the diagnostic and treatment strategies undertaken in this patient. Our case study suggests that every person with hypoparathyroidism of unknown origin, particularly if this disorder is accompanied by abnormal gonadal function, should be assessed for the possible presence of hereditary hemochromatosis.
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Ital J Pediatr
January 2025
Department of Pediatrics, IRCCS Policlinico San Matteo Foundation, Viale Golgi 19, Pavia, 27100, Italy.
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Ultrasound Diagnosis Department, Maternal and Child Health Hospital of Hubei Province, Wuhan, 430070, China.
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Immunopharmacol Immunotoxicol
January 2025
College of Pharmacy, Changsha Medical University, Changsha, Hunan, 410219, China.
Nivolumab has been linked to occurrences of uveitis, yet the clinical features associated with these episodes remain unclear. This study aimed to explore the clinical characteristics of uveitis induced by nivolumab and to offer guidance for its prevention, diagnosis, and treatment. We conducted a retrospective analysis by gathering case reports related to nivolumab-induced uveitis from both Chinese and English databases, covering the period from inception until September 30, 2024.
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Department of Pediatric Respiratory Medicine, Children's Hospital, Maternal and Child Health Hospital of Guangxi Zhuang Autonomous Region, Nanning, 530003, People's Republic of China.
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View Article and Find Full Text PDFClin Investig Arterioscler
January 2025
Unitat de Recerca de Lípids i Arteriosclerosi, Universitat Rovira i Virgili, 43201 Reus, Spain; Institut d'Investigació Sanitària Pere Virgili (IISPV), 43007 Reus, Spain; Centro de Investigación Biomédica en Red de Diabetes y Enfermedades Metabólicas Asociadas, 28029 Madrid, Spain. Electronic address:
Introduction: Rheumatoid arthritis (RA) is an autoimmune and inflammatory disorder that leads to cartilage and bone deterioration. This inflammatory activity causes extra-articular manifestations, including the acceleration of the atherosclerotic process. However, the exact causes of this accelerated process are under investigation.
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