Sarcomatoid carcinoma (SC) is a rare primary malignant tumor in which both carcinomatous and sarcomatous elements occur. It can occur in many different organs and anatomical locations, such as the skin, thyroid gland, bone, urinary tract, breast, pancreas, liver and other areas. Of them, pulmonary sarcomatoid carcinoma (PSC) is a rare malignant cancer composed of sarcoma and sarcoma-like tumors with spindle or giant cell features. Here a case of a 75-year-old Chinese man with a six-month history of cough and hemoptysis is reported. Chest X-ray showed a tumor shadow in the left lung field. Chest computed tomography (CT) scan showed a lobulated mass in his left hilum and even the left pulmonary artery. Pleomorphic interstitial cells were found by bronchoscopic brushing. To establish a definitive diagnosis for PSC, a left pneumonectomy was performed. The pathological stage was IIB (pT2N1M0) based on the tumor node metastasis (TNM) staging system. The tumor's pathology, histology, immunohistochemistry and treatment methods are discussed.
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http://dx.doi.org/10.5114/wo.2013.34375 | DOI Listing |
Eur Ann Otorhinolaryngol Head Neck Dis
March 2025
Service de chirurgie digestive, CHU Saint-Etienne, avenue Albert-Raimond, 42270 Saint-Priest-en-Jarez, France.
Objective: To report a case of duodenal metastasis of laryngeal squamous cell carcinoma revealed by acute intestinal obstruction.
Case Report: A 55-year-old male was initially treated for cT4N1M0 laryngeal squamous cell carcinoma, with total laryngectomy, bilateral neck dissection, total thyroidectomy and pectoralis major flap. Subsequently, he received radiotherapy and chemotherapy.
Transplant Proc
March 2025
Graduate School of Bengbu Medical University, Bengbu Medical University, Bengbu, Anhui, China; Department of Liver Transplantation, The First Affiliated Hospital of USTC, Division of Life Science and Medicine, University of Science and Technology of China, Hefei, Anhui, China. Electronic address:
Immunotherapy, primarily with immune checkpoint inhibitors, has become pivotal in the treatment of advanced hepatocellular carcinoma (HCC), leading to significant tumor burden reduction. However, its applicability in liver transplantation remains controversial. Due to the potential risks of rejection limiting large-scale clinical trials and the incomplete understanding of underlying mechanisms, whether transplant recipients can benefit from immunotherapy remains uncertain.
View Article and Find Full Text PDFGenome Res
March 2025
Broad Institute of MIT and Harvard, Cambridge, Massachusetts 02142, USA;
Gene fusions are found as cancer drivers in diverse adult and pediatric cancers. Accurate detection of fusion transcripts is essential in cancer clinical diagnostics and prognostics and for guiding therapeutic development. Most currently available methods for fusion transcript detection are compatible with Illumina RNA-seq involving highly accurate short-read sequences.
View Article and Find Full Text PDFBMJ Case Rep
March 2025
Ophthalmology, Northwestern University Feinberg School of Medicine, Chicago, Illinois, USA
We present a case of sebaceous carcinoma presenting as treatment-resistant chalazion. Diagnosis was made by excisional biopsy after failed treatment with warm compresses, eyelid hygiene and erythromycin ointment. Conjunctival map biopsies excluded local spread.
View Article and Find Full Text PDFJ Immunother Cancer
March 2025
Team "Biologie des Infections à Polyomavirus", UMR1282, Tours, France.
The cell adhesion protein CD56 has been identified as a potential therapeutic target in several solid tumors and hematological malignancies. Recently, we developed a CD56-directed antibody-drug conjugate (ADC), called Adcitmer and demonstrated its antitumor properties in preclinical models of the rare and aggressive skin cancer Merkel cell carcinoma (MCC).The present study aims to further optimize Adcitmer to overcome the therapeutic limitations observed with previously evaluated CD56-targeting ADCs, which were partially related to toxic effects on leukocytes.
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