Background: Nevus spilus (NS) is a potential precursor of melanoma; the vast majority of cases reported in the literature were histologically classified as superficial spreading melanoma.

Objective: To demonstrate the diagnostic value of reflectance confocal microscopy (RCM) in this subtype of congenital nevi.

Methods: We report a case of a large congenital NS with equivocal clinical and dermoscopic findings in which RCM was applied for diagnosis and follow-up.

Results: There was a good correlation of RCM with histopathology and a lack of dynamic changes during follow-up.

Conclusion: Our observations indicate that RCM, as a non-invasive tool, can be useful for diagnosis and follow-up of clinically and dermoscopically equivocal NS.

Download full-text PDF

Source
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3663396PMC
http://dx.doi.org/10.5826/dpc.0302a08DOI Listing

Publication Analysis

Top Keywords

large congenital
8
reflectance confocal
8
confocal microscopy
8
congenital nevus
4
nevus spilus-improved
4
spilus-improved follow-up
4
follow-up vivo
4
vivo reflectance
4
microscopy background
4
background nevus
4

Similar Publications

Background: Early life gut microbiota is known to shape the immune system and has a crucial role in immune homeostasis. Only little is known about composition and dynamics of the intestinal microbiota in infants with congenital heart disease (CHD) and potential influencing factors.

Methods: We evaluated the intestinal microbial composition of neonates with CHD ( = 13) compared to healthy controls (HC,  = 30).

View Article and Find Full Text PDF

Klippel-Feil syndrome (KFS) is a rare congenital disorder characterized by the fusion of cervical vertebrae, with a clinical presentation that can vary widely due to genetic and phenotypic diversity. While KFS can occur as an isolated anomaly, it is often associated with other congenital conditions, such as Sprengel deformity, which may present with or without an omovertebral bone, complicating diagnosis and management. This particular case also involves diffuse large B-cell lymphoma (DLBCL), the most common subtype of non-Hodgkin lymphoma.

View Article and Find Full Text PDF

Rhabdomyosarcoma (RMS) is the most common soft tissue sarcoma in children, presenting with heterogeneous clinical and molecular subtypes. While gene fusions are predominantly associated with alveolar RMS, spindle cell RMS, especially congenital and intraosseous variants, are also linked to specific gene fusions. Furthermore, recently, FGFR1 kinase-driven RMSs were published.

View Article and Find Full Text PDF

Background: Transcatheter closure of large and complex atrial septal defect can pose challenges and complications during device placement. To improve stability, several assistive techniques have been developed.

Methods: This retrospective study evaluated the efficacy of the device-assisted device closure technique for large secundum atrial septal defects.

View Article and Find Full Text PDF

Introduction: Classic congenital adrenal hyperplasia due to 21-hydroxylase deficiency (CAH) is a rare genetic condition characterized by cortisol deficiency and excess adrenal androgens. CAH treatment is a lifelong balancing act between the need to reduce excess androgens, typically with supraphysiologic glucocorticoid (GC) doses, and concerns about potentially serious GC-related adverse events. Tradeoffs between the consequences of excess androgens versus GCs must be constantly reassessed throughout each patient's lifetime, based on current clinical needs and treatment goals.

View Article and Find Full Text PDF

Want AI Summaries of new PubMed Abstracts delivered to your In-box?

Enter search terms and have AI summaries delivered each week - change queries or unsubscribe any time!