AI Article Synopsis
- Intermittent compression of the hepatoduodenal ligament during liver surgery can lead to ischemia-reperfusion injury, affecting both local and distant tissues and influencing surgical outcomes based on the duration of blood flow interruption.
- An animal study on 12 Beagle dogs investigated the effects of the Baron/Pringle maneuver, revealing significant histological changes in the liver and small intestine after clamping for three 15-minute intervals with 30-minute reperfusion.
- Liver function tests showed elevated GPT levels as the earliest marker, with increases in GOT and LDH also noted, indicating that the third 15-minute compression was excessive for optimal liver function.
Article Abstract
Intermittent compression of the structures of the hepatoduodenal ligament, is often performed during liver surgery. As a result, changes in hepatic blood supply and consequent reperfusion induced tissue damages will develop. Ischemia-reperfusion injury, which occur in local and distant regions, influence outcome of hepatic surgery, and it is in close correlation with the duration of hypoxia during the intervention. In animal model the effect of Baron/Pringle manoeuvre was investigated in terms of changes in liver function tests and histology. The study was carried out on 12 Beagle dogs, clamping of the hepatoduodenal ligament for 3×15 minutes then half an hour reperfusion was performed followed by blood and tissue sampling. Significant histological changes were observed both in the liver as well as the small intestine. In terms of liver function changes, GPT elevation occurred the earliest, GOT and LDH were also increased at the end of the 30 minutes reperfusion. In this animal model, the third 15 minutes compression turned out to be too long. Elevation in GPT levels was the most sensitive marker.
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| http://dx.doi.org/10.1556/MaSeb.66.2013.3.7 | DOI Listing |
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