Introduction: A simple, economical, precise, and accurate new UV spectrophotometric baseline manipulation methodology for simultaneous determination of drotaverine (DRT) and etoricoxib (ETR) in a combined tablet dosage form has been developed.
Materials And Methods: The method is based on baseline manipulation (difference) spectroscopy where the amplitudes at 274 and 351 nm were selected to determine ETR and DRT, respectively, in combined formulation and methanol was used as solvent. Both the drugs obey Beer's law in the concentration ranges of 4-20 μg/mL for DRT and 4.5-22.5 μg/mL for ETR.
Results: The results of analysis have been validated statistically and recovery studies confirmed the accuracy and reproducibility of the proposed method which were carried out by following the ICH guidelines.
Conclusion: It has been concluded that a new simple and accurate UV spectrophotometric baseline manipulation method was developed for simultaneous do not declare DRT and ETR in a combined tablet dosage form has been developed.
Download full-text PDF |
Source |
|---|---|
| http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3658078 | PMC |
| http://dx.doi.org/10.4103/2229-4708.93395 | DOI Listing |
Publication Analysis
Top Keywords
Similar Publications
Effects of spectral manipulations of music mixes on musical scene analysis abilities of hearing-impaired listeners.
PLoS One
January 2025
Dept. of Medical Physics and Acoustics, Carl von Ossietzky University of Oldenburg, Oldenburg, Germany.
Music pre-processing methods are currently becoming a recognized area of research with the goal of making music more accessible to listeners with a hearing impairment. Our previous study showed that hearing-impaired listeners preferred spectrally manipulated multi-track mixes. Nevertheless, the acoustical basis of mixing for hearing-impaired listeners remains poorly understood.
View Article and Find Full Text PDFEffects of Manual Therapy on Fascial Distortion Model in Adolescent Ankle Sprain: A Pilot Study.
J Chiropr Med
September 2024
Department of Public Health Medicine, Medical School, University of Pécs, Pécs, Hungary.
Objectives: The present study aimed to assess the feasibility of investigating the effects of manual therapy on ankle functional muscle strength, static balance, and disability in adolescent patients with an ankle sprain.
Methods: The study was a nonrandomized prepost clinical feasibility trial. From September 2021 to February 2022, 31 patients with ankle sprain received manual therapy.
Subthalamic nucleus deep brain stimulation in the beta frequency range boosts cortical beta oscillations and slows down movement.
J Neurosci
January 2025
Institute of Clinical Neuroscience and Medical Psychology, Medical Faculty and University Hospital Düsseldorf, Heinrich Heine University Düsseldorf, 40225 Germany
Recordings from Parkinson's disease (PD) patients typically show strong beta-band oscillations (13-35Hz), which can be modulated by deep brain stimulation (DBS). While high-frequency DBS (>100Hz) ameliorates motor symptoms and reduces beta activity in basal ganglia and motor cortex, the effects of low-frequency DBS (<30Hz) are less clear. Clarifying these effects is relevant for the debate about the role of beta oscillations in motor slowing, which might be causal or epiphenomenal.
View Article and Find Full Text PDFEffectiveness of an 8-week neck exercise training on pain, jaw function, and oral health-related quality of life in women with chronic temporomandibular disorders: a randomized controlled trial.
J Oral Facial Pain Headache
March 2024
Faculty of business and Social Sciences, University of Applied Sciences, 49076 Osnabrück, Germany.
To test the effectiveness of an 8-week exercise program targeted to the neck muscles compared to manual therapy, and placebo treatments on orofacial pain intensity, jaw function, oral health-related quality of life (OHRQoL), and jaw range of motion (ROM) in women with Temporomandibular Disorders (TMD). In this randomized controlled trial, fifty-four women (between 18-45 years old) with a diagnosis of myofascial or mixed TMD according to the Research Diagnostic Criteria for TMD (RDC/TMD) were randomized into three groups: Neck motor control training (NTG), Manual Therapy Group (MTG), and Placebo Group (PG). All patients were evaluated with the Visual Analog Scale, Mandibular Function Impairment Questionnaire, Oral Health Impact Profile-14, and jaw Range of Motion (ROM) at baseline, immediately after treatment (after 8 weeks of treatment), one month, and three-month follow-up.
View Article and Find Full Text PDFInfluence of cadence manipulation on running biomechanics in high school cross-country runners.
Sports Biomech
January 2025
School of Exercise and Rehabilitation Sciences, The University of Toledo, Toledo, OH, USA.
Increasing cadence is an intervention to reduce injury risk for adolescent long-distance runners. It is unknown how adolescents respond biomechanically when running with a higher than preferred cadence. We examined the influence of increasing cadence on peak joint angles, moments and powers, and ground reaction forces in long-distance runners.
View Article and Find Full Text PDFWant AI Summaries of new PubMed Abstracts delivered to your In-box?
Enter search terms and have AI summaries delivered each week - change queries or unsubscribe any time!