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Tumor-targeted photodynamic therapy. | LitMetric

Tumor-targeted photodynamic therapy.

Anticancer Res

Department of Biochemistry, Faculty of Medicine, Fukuoka University, Nanakuma, Jonan-ku, Fukuoka, Japan.

Published: July 2013

AI Article Synopsis

  • * Traditional photosensitizers aren't very selective, often affecting nearby healthy tissues and causing side effects.
  • * New strategies for tumor-targeted PDT aim to improve selectivity and effectiveness by focusing the treatment specifically on cancerous tissues.

Article Abstract

Photodynamic therapy (PDT) is a well-established clinical treatment modality for various diseases, including cancer. It involves the topical or systemic administration of a photosensitizer, followed by selective irradiation of the target lesion with a specific wavelength of non-ionizing light, which triggers oxidative photodamage and subsequent death of the targeted cells. Due to this two-step therapeutic process, PDT is a safe and minimally-invasive therapy. Nevertheless, classical non-targeted photosensitizers lack sufficient tumor selectivity and are taken up in the neighboring normal tissues, resulting in undesirable adverse effects. To overcome this obstacle, diverse tumor-targeting approaches have been developed. In this article, we discuss the current strategies and rationale regarding tumor-targeted PDT.

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