The authors analyze the efficacy of microdiathermocoagulation (MDC) in 126 patients with herpetic keratitis. Combined use of MDC and soft contact highly hydrophilic lenses preimpregnated with poludan, an interferon inductor solution, has helped reduce almost twofold the mean period of treatment of 80 patients with dendritic keratitis as compared to idoxuridine monotherapy. The study has shown the advantages of a soft contact lens over ointment dressing prescribed after such microsurgical manipulations to patients with superficial herpetic keratitis. A special microelectrode scarifier is suggested. The efficacy of MDC in the treatment of herpetic stromal keratitis with ulceration has been demonstrated, as well as in the management of superinfection manifestations (purulent ulcer, abscess of the cornea). The technique and the results of MDC are discussed and compared to mechanical abrasion and argon laser coagulation in herpetic keratitis.
Download full-text PDF |
Source |
|---|
Publication Analysis
Top Keywords
Similar Publications
Lucia Keratoprosthesis in a Sclerocorneal Graft for Recurrent Graft Rejection Secondary to Herpetic Keratitis.
Cornea
January 2025
Instituto de Oftalmologia Fundacion Conde de Valenciana IAP, Mexico City, Mexico.
Purpose: To report the surgical approach of a Lucia keratoprosthesis (KPro) on a sclerocorneal graft in the setting of recurrent graft rejection and perilimbal scleral thinning.
Methods: A case report.
Results: We report the case of a 26-year-old man with a history of herpes simplex keratitis, 2 penetrating keratoplasties, graft failure, secondary glaucoma, and a conjunctival flap in the right eye who underwent a Lucia KPro, lens extraction, glaucoma drainage device, and pars plana vitrectomy.
Possible viral agents to consider in the differential diagnosis of blepharoconjunctivitis.
World J Virol
December 2024
Department of Ophthalmology, University Hospital of Udine, Udine 33100, Italy.
Background: Blepharoconjunctivitis poses a diagnostic challenge due to its diverse etiology, including viral infections. Blepharoconjunctivits can be acute or chronic, self-limiting, or needing medical therapy.
Aim: To review possible viral agents crucial for accurate differential diagnosis in cases of blepharoconjunctivitis.
JAG1 mediates apoptosis in herpes simplex keratitis by suppressing autophagy via ROS/JAG1/NOTCH1/pULK1 signaling pathway.
Cell Biol Toxicol
December 2024
Department of Ophthalmology, Nanjing Drum Tower Hospital, Nanjing, 210011, Jiangsu, China.
Herpes simplex keratitis (HSK), an ocular disease resulted from herpes simplex virus type 1 (HSV-1) infection, leads to the majority of infectious corneal blindness worldwide. The apoptosis of corneal epithelial cells (CECs) resulted from HSV-1 disrupts the epithelial barrier and exacerbates the infection; however, there is no definitive cure for HSK. Jagged1 (JAG1), one of the primary functional ligands for NOTCH receptors, plays a crucial role in regulating apoptosis and autophagy; however, its role in HSK is unclear.
View Article and Find Full Text PDFDevelopment of silk fibroin/collagen film containing GI-20 peptide-loaded PLGA nanoparticles against corneal herpes simplex virus-1.
Int J Pharm
January 2025
Department of Biotechnology Engineering, School of Chemical Engineering, College of Engineering, University of Tehran, Tehran, Iran.
Herpes simplex virus-1 (HSV-1) is the primary cause of infectious blindness. Despite impressive therapeutic outcomes of conventional treatments, HSV-1 drug resistance can be easily developed. Thus, more constructive strategies should be implemented.
View Article and Find Full Text PDFCalcifediol and paricalcitol as adjunctive therapies for HSV-1 keratitis and corneal perforation: A case report.
Medicine (Baltimore)
December 2024
Laboratory of Neurobiology, Department of Medical Biology and Genetics, Faculty of Medicine Osijek, J. J. Strossmayer University of Osijek, Osijek, Croatia.
Rationale: Herpes simplex virus 1 establishes a latent infection in trigeminal ganglia. Reactivation causes cold sores, as well as viral keratitis. The purpose of this study was to report potential benefits of using active vitamin D receptor ligands (VDR-agonists) as adjunctive therapies for the treatment of infectious corneal perforations, and prevention of HSV recurrence.
View Article and Find Full Text PDFWant AI Summaries of new PubMed Abstracts delivered to your In-box?
Enter search terms and have AI summaries delivered each week - change queries or unsubscribe any time!