AI Article Synopsis
- Previous research has established the antioxidant properties of epigallocatechin gallate (EGCG) and alpha lipoic acid (ALA), particularly in kidney injury, but further investigation into their protective effects is ongoing.
- The study found that EGCG effectively reduced inflammation markers and downregulated harmful protein expressions in kidney cells exposed to high glucose levels, while both EGCG and ALA improved antioxidant enzyme production and lowered reactive oxygen species (ROS).
- Combining EGCG and ALA showed a stronger effect in anti-inflammatory and antioxidant activities compared to EGCG alone, highlighting their potential as a treatment to slow down diabetic nephropathy progression.
Article Abstract
The anti-oxidant effects of epigallocatechin gallate (EGCG) and alpha lipoic acid (ALA) have been demonstrated in previous studies. The kidney protection effects of EGCG and ALA in patients with kidney injury are still under investigation. The purpose of this study is to investigate the anti-inflammatory and anti-oxidant effects of EGCG and ALA on high glucose-induced human kidney cell damage. EGCG inhibited high glucose(HG)-induced TNF-α and IL-6 production in human embryonic kidney (HEK) cells. Both EGCG and ALA decreased HG-induced receptor of advanced glycation end products (RAGE) mRNA and protein expressions in HEK cells. EGCG and ALA also recovered HG-inhibited superoxide dismutase production and decreased ROS expressions in HEK cells. The synergism of EGCG and ALA was also studied. The effect of EGCG combined with ALA is greater than the effect of EGCG alone in all anti-inflammation and anti-oxidant experiments. Our studies provide a potential therapeutic application of EGCG and ALA in preventing progression of diabetic nephropathy.
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| http://dx.doi.org/10.1590/S0001-37652013005000023 | DOI Listing |
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