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Ventilation and features of the lung environment dynamically alter modeled intrapulmonary aerosol exposure from inhaled electronic cigarettes.
Sci Rep
December 2024
Division of Pulmonary and Critical Care, Department of Medicine, David Geffen School of Medicine, University of California, Los Angeles, CA, 90095-1690, USA.
Electronic cigarettes (e-cigs) fundamentally differ from tobacco cigarettes in their generation of liquid-based aerosols. Investigating how e-cig aerosols behave when inhaled into the dynamic environment of the lung is important for understanding vaping-related exposure and toxicity. A ventilated artificial lung model was developed to replicate the ventilatory and environmental features of the human lung and study their impact on the characteristics of inhaled e-cig aerosols from simulated vaping scenarios.
View Article and Find Full Text PDFCycling Isokinetic Peak Force Explains Maximal Aerobic Power and Physiological Thresholds but Not Cycling Economy in Trained Triathletes.
J Funct Morphol Kinesiol
December 2024
Unidad de Fisiología del Ejercicio, Centro de Innovación, Clínica MEDS, Santiago 7550615, Chile.
: Assessments of muscle strength help prescribe and monitor training loads in cyclists (e.g., triathletes).
View Article and Find Full Text PDFCorticosteroids in Pediatric Septic Shock: A Narrative Review.
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Neonatal and Pediatric Intensive Care Unit, University Hospital of Messina, 98124 Messina, Italy.
A controversial aspect of pediatric septic shock management is corticosteroid therapy. Current guidelines do not recommend its use in forms responsive to fluids and inotropes but leave the decision to physicians in forms refractory to the first steps of therapy. Review of literature from January 2013 to December 2023 from online libraries Pubmed, Medline, Cochrane Library, and Scopus.
View Article and Find Full Text PDFLung Transplant Success in COVID-19 Patients Requiring V-V ECMO: One-Year Follow-Up.
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December 2024
Division of Pulmonary Medicine, Critical Care, Sleep Medicine, and Physiology, Department of Medicine, University of California San Diego, La Jolla, CA, USA.
BACKGROUND Acute respiratory distress syndrome (ARDS) due to coronavirus 2019 (COVID-19) can result in severe disease requiring mechanical ventilatory support. A subset of these patients, however, demonstrate refractory hypoxemia/hypercarbia requiring veno-venous extracorporeal membrane oxygenation (V-V ECMO) as adjunctive therapy. The primary goal of V-V ECMO is a "bridge" to recovery of native lung function; however, patients may progress to irreversible pulmonary damage requiring lung transplantation.
View Article and Find Full Text PDFPredictors of Functional Impairment in Severe COVID-19 Patients Two Months After Discharge.
Ther Adv Pulm Crit Care Med
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Department of Pulmonary and Critical Care Medicine, Hôtel-Dieu de France University, Medical Center (HDFUMC) of the Saint-Joseph University of Beirut (USJ), Beirut, Lebanon.
Background: The Post-COVID-19 Functional Status (PCFS) scale is a validated tool used to measure the functional status of patients discharged from the hospital.
Objectives: To describe the functional limitations of hospitalized COVID-19 patients at the time of discharge and two months afterward, and to identify risk factors associated with functional impairment.
Design: Retrospective study.
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