We measured the abundance of sarcoplasmic masses within skeletal muscle myocytes of an adult female stranded pigmy sperm whale (Kogia breviceps). The presence of these masses in other species has been reported in association with myopathies, including myotonic dystrophy, the most frequently related pathology. Other histopathologic muscle changes included a high number of internal nuclei, variations in fiber size and shape, and the predominance of type I fibers.
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Int J Mol Sci
June 2024
Toronto General Hospital Research Institute, University Health Network, Toronto, ON M5G 2M1, Canada.
Cardiac arrhythmias remain a significant concern with Ibrutinib (IBR), a first-generation Bruton's tyrosine kinase inhibitor (BTKi). Acalabrutinib (ABR), a next-generation BTKi, is associated with reduced atrial arrhythmia events. However, the role of ABR in ventricular arrhythmia (VA) has not been adequately evaluated.
View Article and Find Full Text PDFHeart Rhythm
December 2023
The Hull Family Cardiac Fibrillation Management Laboratory, Toronto General Hospital, University Health Network, Toronto, Ontario, Canada. Electronic address:
Myocardial calcium (Ca) signaling plays a crucial role in contractile function and membrane electrophysiology. An abnormal myocardial Ca transient is linked to heart failure and ventricular arrhythmias. At the subcellular level, the synchronous release of Ca sparks from sarcoplasmic Ca release units determines the configuration and amplitude of the global Ca transient.
View Article and Find Full Text PDFBiomaterials
October 2023
Division of Cardiology and Peter Munk Cardiac Center, University Health Network, Toronto, ON, M5G 1L7, Canada; Department of Biology, York University, Toronto, ON, M3J 1P3, Canada; Terrence Donnelly Centre for Cellular & Biomolecular Research, University of Toronto, Toronto, ON, M5S 3E1, Canada. Electronic address:
CJC Open
December 2022
Toronto General Hospital Research Institute, University of Toronto, Toronto, Ontario, Canada.
Background: Doxorubicin-induced cardiomyopathy (DICM) is one of the complications that can limit treatment for a significant number of cancer patients. In animal models, the administration of statins can prevent the development of DICM. Therefore, the use of statins with anthracyclines potentially could enable cancer patients to complete their chemotherapy without added cardiotoxicity.
View Article and Find Full Text PDFJACC CardioOncol
November 2020
The Hull Family Cardiac Fibrillation Management Laboratory, Toronto General Hospital, Toronto, Ontario, Canada.
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