Sarcoplasmic masses in the skeletal muscle of a stranded pigmy sperm whale (Kogia breviceps).

J Wildl Dis

Department of Veterinary Pathology, Institute for Animal Health, Veterinary School, Universidad de Las Palmas de Gran Canaria, Trasmontaña S/N, 35416, Arucas, Las Palmas, Spain.

Published: July 2013

AI Article Synopsis

  • The study focused on skeletal muscle myocytes in an adult female pygmy sperm whale, measuring the abundance of sarcoplasmic masses.
  • Findings suggest that these masses are linked to muscle diseases, particularly myotonic dystrophy, which is often associated with such conditions in other species.
  • Additional muscle changes included a high count of internal nuclei, variations in fiber size and shape, and a predominance of type I muscle fibers.

Article Abstract

We measured the abundance of sarcoplasmic masses within skeletal muscle myocytes of an adult female stranded pigmy sperm whale (Kogia breviceps). The presence of these masses in other species has been reported in association with myopathies, including myotonic dystrophy, the most frequently related pathology. Other histopathologic muscle changes included a high number of internal nuclei, variations in fiber size and shape, and the predominance of type I fibers.

Download full-text PDF

Source
http://dx.doi.org/10.7589/2012-04-103DOI Listing

Publication Analysis

Top Keywords

sarcoplasmic masses
8
masses skeletal
8
skeletal muscle
8
stranded pigmy
8
pigmy sperm
8
sperm whale
8
whale kogia
8
kogia breviceps
8
muscle stranded
4
breviceps measured
4

Similar Publications

Cardiac arrhythmias remain a significant concern with Ibrutinib (IBR), a first-generation Bruton's tyrosine kinase inhibitor (BTKi). Acalabrutinib (ABR), a next-generation BTKi, is associated with reduced atrial arrhythmia events. However, the role of ABR in ventricular arrhythmia (VA) has not been adequately evaluated.

View Article and Find Full Text PDF

Restoration of calcium release synchrony: A novel target for heart failure and ventricular arrhythmia.

Heart Rhythm

December 2023

The Hull Family Cardiac Fibrillation Management Laboratory, Toronto General Hospital, University Health Network, Toronto, Ontario, Canada. Electronic address:

Myocardial calcium (Ca) signaling plays a crucial role in contractile function and membrane electrophysiology. An abnormal myocardial Ca transient is linked to heart failure and ventricular arrhythmias. At the subcellular level, the synchronous release of Ca sparks from sarcoplasmic Ca release units determines the configuration and amplitude of the global Ca transient.

View Article and Find Full Text PDF

Maturation of iPSC-derived cardiomyocytes in a heart-on-a-chip device enables modeling of dilated cardiomyopathy caused by R222Q-SCN5A mutation.

Biomaterials

October 2023

Division of Cardiology and Peter Munk Cardiac Center, University Health Network, Toronto, ON, M5G 1L7, Canada; Department of Biology, York University, Toronto, ON, M3J 1P3, Canada; Terrence Donnelly Centre for Cellular & Biomolecular Research, University of Toronto, Toronto, ON, M5S 3E1, Canada. Electronic address:

Article Synopsis
  • The study focused on understanding SCN5A-related cardiomyopathies by creating ventricular cardiomyocytes from stem cells of a dilated cardiomyopathy patient with the R222Q mutation.
  • Using heart-on-a-chip biowires, researchers found that the R222Q mutation led to arrhythmias, altered sodium channel properties, and decreased heart muscle contractility compared to controls.
  • RNA sequencing revealed significant differences in gene regulation affecting calcium handling and sarcomere structure, highlighting the mutation's impact on both cardiac electrical activity and mechanical stability.
View Article and Find Full Text PDF

Background: Doxorubicin-induced cardiomyopathy (DICM) is one of the complications that can limit treatment for a significant number of cancer patients. In animal models, the administration of statins can prevent the development of DICM. Therefore, the use of statins with anthracyclines potentially could enable cancer patients to complete their chemotherapy without added cardiotoxicity.

View Article and Find Full Text PDF
Article Synopsis
  • The study investigates how the drug ibrutinib affects the heart's electrical activity and the risk of dangerous heart rhythms (ventricular arrhythmia, VA) in both young and old spontaneous hypertensive rats.
  • It finds that older rats treated with ibrutinib showed significantly higher vulnerability to ventricular fibrillation compared to younger rats, indicating age-related risks associated with the medication.
  • The results suggest that changes in calcium dynamics and action potential duration in the heart are crucial factors in the pro-arrhythmic effects of ibrutinib, particularly in older individuals.
View Article and Find Full Text PDF

Want AI Summaries of new PubMed Abstracts delivered to your In-box?

Enter search terms and have AI summaries delivered each week - change queries or unsubscribe any time!