Biological market theory predicts that animals exchange the same commodities, or interchange different ones, to their mutual benefit. Using focal and behavioral sampling methods and continuous recording techniques, we studied Tibetan macaques (Macaca thibetana) in two study groups (YA1 and YA2) at Huangshan, China to see whether adults interchanged male-to-female agonistic support for copulation. Overall, male-to-female agonistic support was significantly correlated with copulation behaviors when data from both study groups were combined. For YA1, copulations in post-agonistic support observation (PO) was greater, but not significantly so, than random observation (RO) in the breeding season, and copulation in PO was significantly greater than RO in the non-breeding season. For YA2 copulations in PO were significantly greater than RO in both breeding and non-breeding seasons. These results suggest that a male who extends post-agonistic support to a female is significantly more likely to copulate with her. Our study provides evidence for the existence of a biological market involving interchanged social behaviors. Our study also illuminates the reproductive strategies of male competition and female choice in this species.
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Nat Cancer
January 2025
Center for Cancer Research, Medical University of Vienna, Comprehensive Cancer Center, Vienna, Austria.
Dendritic cell (DC) activation by pattern recognition receptors like Toll-like-receptors (TLRs) is crucial for cancer immunotherapies. Here, we demonstrate the effectiveness of the TLR7/8 agonist imiquimod (IMQ) in treating both local tumors and distant metastases. Administered orally, IMQ activates plasmacytoid DCs (pDCs) to produce systemic type I interferons (IFN-I) required for TLR7/8 upregulation in DCs and macrophages, sensitizing them to topical IMQ treatment, which is essential for therapeutic efficacy.
View Article and Find Full Text PDFAm J Emerg Med
January 2025
Department of Emergency Medicine, Hospital of the University of Pennsylvania, Philadelphia, PA, USA.
Background: Gastrointestinal symptoms of acute opioid withdrawal are distressing for patients and are often difficult to manage with conventional therapies. Insufficiently managed opioid withdrawal symptoms may lead patients to leave against medical advice, which can increase their risk of relapse and result in poor outcomes from untreated conditions. We assessed the impact of an erector spinae plane block on the acute gastrointestinal symptoms of opioid withdrawal.
View Article and Find Full Text PDFPhytomedicine
January 2025
The Second Hospital of Shandong University, Jinan, Shandong, PR China; Advanced Medical Research Institute, Shandong University, Shandong University, Jinan, Shandong, PR China. Electronic address:
Background: The prevalence of obesity and its associated diseases has sharply increased, becoming a global health issue. White adipose tissue (WAT), responsible for lipid storage via hyperplasia and hypertrophy, and brown adipose tissue (BAT), which facilitates energy dissipation, have increasingly been recognized as critical regulators of weight loss. Shouhui Tongbian Capsule (SHTB) has traditionally been used for detoxification, weight loss, and lipid reduction, and clinical evidence supports its use for relieving constipation.
View Article and Find Full Text PDFDrug Alcohol Depend Rep
March 2025
Center to Improve Veteran Involvement in Care, VA Portland Health Care System, 3710 SW US Veterans Hospital Rd, Portland, OR 97239, United States.
Aim: We examined differences in medications for opioid use disorder (MOUD) receipt between rural and urban veteran patients following initiatives within the US Department of Veterans Affairs (VA) to expand access to MOUD.
Methods: Data for this retrospective cohort study were obtained from the VA Corporate Data Warehouse, which contains national electronic health record data for all VA patients. The analytic sample included all patients diagnosed with OUD from 10/1/2018-9/30/20.
Cureus
December 2024
Department of Dermatology, Duke University Medical Center, Durham, USA.
Folliculitis decalvans (FD) is a chronic inflammatory alopecia characterized by painful, scarring lesions and recurrent flares, often complicated by secondary bacterial infections. Despite the use of topical and systemic anti-inflammatory or antimicrobial therapies, FD remains challenging to manage, with limited therapeutic advancements. We report a case of recalcitrant FD in a man in his 40s who experienced significant symptom improvement and hair regrowth following the initiation of tirzepatide for weight management.
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