AI Article Synopsis
- Three new alkaloids and one new phenolic compound were extracted from the bulbs of the Lycoris aurea plant in Hunan Province, China.
- Their chemical structures were determined using various spectroscopic techniques such as HRESIMS, UV, IR, and NMR.
- The isolated compounds were tested for neuroprotective properties, with several showing significant protective effects against cell death induced by CoCl2 and H2O2 in SH-SY5Y cells.
Article Abstract
Three new alkaloids, 2α-hydroxy-6-O-n-butyloduline, O-n-butyllycorenine, (-)-N-(chloromethyl)lycoramine (1-3), and a new phenolic compound, ((7S)-7-(4-hydroxyphenyl)-7-hydroxypropyl)-2'-methylbenzene-3',6'-diol (14), along with ten known alkaloids (4-13), were isolated from the bulbs of Lycoris aurea collected from Huaihua County of Hunan Province, China. Their structures were elucidated by spectroscopic methods including HRESIMS, UV, IR, and NMR. All the isolated compounds were tested for their neuroprotective effects against CoCl2 and H2O2-induced SH-SY5Y cell death. Compounds 1-7 and 10 exhibited significant neuroprotective effects against CoCl2-induced SH-SY5Y cell injury, while compounds 1-5, 7, 10 and 12 showed obvious neuroprotective effects against H2O2-induced SH-SY5Y cell death.
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| http://dx.doi.org/10.1007/s12272-013-0188-1 | DOI Listing |
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