Tribute to Professor André Vincent (1931-2023).

Alkaptonuria (AKU) is an extremely rare autosomal recessive metabolic disorder caused by deficiency of homogentisic acid oxidase and resulting in accumulation of homogentisic acid in collagenous structures. It is characterized by a triad of homogentisic aciduria, bluish-black discoloration of connective tissues (ochronosis) and arthropathy of large weight bearing joints. We report on a middle-aged female patient with bilateral severe ochronotic arthritis of both hips and shoulder joints requiring total joint replacements as staged procedures which were done without complications offering a complete pain relief and a satisfactory clinical and functional outcome.

Microfragmented adipose tissue versus platelet-rich plasma in the treatment of knee osteoarthritis: a systematic review and meta-analysis.

This meta-analysis focuses on the controversial efficacy and safety of microfragmented adipose tissue (MFAT) as compared with platelet-rich plasma (PRP) in the clinical treatment of knee osteoarthritis (KOA). We have attempted to provide an evidence-based medicine protocol for the conservative treatment of KOA. Researchers collected and compared randomized controlled trials (RCTs) that used microfragmented adipose tissue and platelet-rich plasma to treat knee osteoarthritis.

The contribution of clock genes BMAL1 and PER2 in osteoarthritis-associated pain.

Joint pain is the primary symptom of osteoarthritis (OA) and the main motivator for patients to seek medical care. OA-related pain significantly restricts joint function and diminishes quality of life. Despite the availability of various pain-relieving medications for OA, current treatment strategies often fall short in delivering adequate pain relief.

Surgical interventions for degenerative cervical disease: Impact on patient quality of life, mental health, pain relief, and spiritual health.

Introduction: Degenerative cervical diseases can severely affect patients' quality of life (QOL), mental health, and physical function. While surgical intervention is a common treatment, its impact on holistic well-being, including spiritual health, has not been thoroughly explored. This study aimed to evaluate the effects of surgery on QOL, pain-related disability, mental health, and spiritual well-being in patients with degenerative cervical diseases.

Current status of nanofat in the management of knee osteoarthritis: A systematic review.

Background: Osteoarthritis (OA) is a prevalent joint disorder requiring innovative treatment approaches.

Aim: To evaluate the use of nanofat, a specialized form of adipose tissue-derived cells, in the treatment of OA, by examining its efficacy, safety profile, mechanisms of action, comparative effectiveness, and long-term outcomes.

Methods: A comprehensive review of preclinical studies, clinical trials, and investigations was conducted.