AI Article Synopsis
- A new method has been created for easily making unsymmetrical urea derivatives using copper as a catalyst for coupling reactions between formamides and amines at room temperature.
- This process allows for direct access to these derivatives, which are important in various chemical applications.
- Additionally, the method is versatile enough to produce chiral urea derivatives, expanding its usefulness in synthesis.
Article Abstract
Direct access to unsymmetrical urea derivatives via copper catalysed C-H/N-H coupling of formamides with amines has been developed at room temperature. This protocol is also applied to the synthesis of chiral urea derivatives.
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| http://dx.doi.org/10.1039/c3cc42381f | DOI Listing |
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