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Adjunctive Pascolizumab in Rifampicin-Susceptible Pulmonary Tuberculosis: Proof-of-Concept, Partially-Randomized, Double-Blind, Placebo-Controlled, Dose-Escalation Trial.
J Infect Dis
September 2024
GSK, Greenford, United Kingdom.
Background: Interleukin 4 (IL-4), increased in tuberculosis infection, may impair bacterial killing. Blocking IL-4 confers benefit in animal models. We evaluated safety and efficacy of pascolizumab (humanized anti-IL-4 monoclonal antibody) as adjunctive tuberculosis treatment.
View Article and Find Full Text PDF[Preliminary study on the effect of on phenotypic transformations of glucose metabolism and polarization types in macrophages].
Zhongguo Xue Xi Chong Bing Fang Zhi Za Zhi
February 2024
Office of Scientific Research Management, Affiliated Hospital of Qinghai University, Xining, Qinghai 810000, China.
Objective: To investigate the effects of on the phenotypic transformations of glucose metabolism, polarization types and inflammatory responses in macrophages, so as to provide insights into elucidation of echinococcosis pathogenesis.
Methods: Bone marrow cells were isolated from C57BL/6J mice at ages of 6 to 8 weeks, and induced into bone marrow-derived macrophages (BMDMs) with mouse macrophage colony-stimulating factor (M-CSF), which served as controls (BMDMs-M0). BMDMs-M0 induced M2 macrophages by interleukin-4 for 24 hours served as the IL-4 induction group, and BMDMs-M0 co-cultured with 2.
Effects of amber LED on inflammatory and regulatory monocytes and lymphocytes.
J Photochem Photobiol B
February 2024
Postgraduate Program in Medicine-Biophotonics, Nove de Julho University (UNINOVE), 235/249 Vergueiro Street, Liberdade, São Paulo, SP 01504-001, Brazil. Electronic address:
The primary objective of the present study was to assess the impact of amber LED photobiomodulation (PBM) on human monocytes and lymphocytes that were polarized into proinflammatory and regulatory/reparative phenotypes. Human leukocytes were polarized with LPS or LPS + IL-4 for 2 h and irradiated after 2 and 6 h with amber LED (590 nm). Cell absorbance spectrum and gene and protein expression of IL-1β, IL-6, IL-10, IL-17, TNF-α and IFNγ determined after 24 h.
View Article and Find Full Text PDF[Study the involvement of Langerin in mediating epicutaneous sensitization of atopic dermatitis-like mouse model].
Zhonghua Yi Xue Za Zhi
October 2023
Hospital for Skin Diseases, Institute of Dermatology, Chinese Academy of Medical Sciences and Peking Union Medical College, Nanjing 210042, China.
To explore the role of Langerin in mediating epicutaneous sensitization of atopic dermatitis (AD) in mouse model. Mice were topically treated with calcipotriol (MC903) plus ovalbumin (OVA) on the ears to establish AD mouse models, and mice were divided into wild-type control group, wild-type AD group, Langerin knockout control group, and Langerin knockout AD group. Changes of lesion were daily observed.
View Article and Find Full Text PDFSingle nucleotide polymorphisms of Interleukin - 4, Interleukin-18, FCRL3 and sPLA2IIa genes and their association in pathogenesis of endometriosis.
Mol Biol Rep
May 2023
Controller of examinations, Tamilnadu Veterinary and Animal sciences university, Chennai, India.
Background: Endometriosis is a complex gynaecological disorder that contributes to infertility, dysmenorrhea, dyspareunia, and other chronic issues. It is a multifactorial disease involving genetic, hormonal, immunological and environmental components. Endometriosis's pathogenesis remains unclear.
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