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High-frequency ultrasound with superb microvascular imaging: a potential tool for ultrasound assessment in patients with giant cell arteritis.
Front Med (Lausanne)
July 2024
Department of Clinical Physiology and Department of Health, Medicine and Caring Sciences, Linköping University, Linköping, Sweden.
Objective: The objective of this study was 2-fold: first, to evaluate whether superb microvascular imaging (SMI) could be used to visualize neovascularization in temporal arteries, and, second, to evaluate the diagnostic performance of high frequency ultrasound with SMI using an extended protocol in patients with suspected giant cell arteritis (GCA).
Methods: This retrospective study comprised 120 patients consecutively examined with an extended CDU protocol (temporal, facial, axillary, subclavian, brachiocephalic, and carotid arteries) between 2020 and 2022. Of all patients, 107 had no previous GCA diagnosis and 13 had a previous GCA diagnosis.
Consensus statement on the processing, interpretation and reporting of temporal artery biopsy for arteritis.
Cardiovasc Pathol
September 2023
Department of Pathology and Laboratory Medicine, University of Ottawa, Ottawa, Ontario, Canada.
Giant cell arteritis (GCA) is the most common systemic vasculitis in adults in Europe and North America, typically involving the extra-cranial branches of the carotid arteries and the thoracic aorta. Despite advances in noninvasive imaging, temporal artery biopsy (TAB) remains the gold standard for establishing a GCA diagnosis. The processing of TAB depends largely on individual institutional protocol, and the interpretation and reporting practices vary among pathologists.
View Article and Find Full Text PDFROS-driven structural and functional fibrinogen modifications are reverted by interleukin-6 inhibition in Giant Cell Arteritis.
Thromb Res
October 2023
Department of Experimental and Clinical Biomedical Sciences "Mario Serio", University of Firenze; viale Pieraccini, 6 - 50139 Firenze, Italy.
Background: Cranial and extra-cranial vascular events are among the major determinants of morbidity and mortality in Giant Cell Arteritis (GCA). Vascular events seem mostly of inflammatory nature, although the precise pathogenetic mechanisms are still unclear. We investigated the role of oxidation-induced structural and functional fibrinogen modifications in GCA.
View Article and Find Full Text PDFPET/CT compared with temporal artery biopsy for giant cell arteritis.
Dan Med J
June 2023
Ear- nose- and throat Department, Regionshospitalet Gødstrup, Denmark.
Introduction: This study aims to evaluate the use of PET/CT compared with temporal artery biopsy (TAB) as a diagnostic tool in patients suspected of giant cell arteritis (GCA) and to determine the influence of glucocorticoid treatment on diagnostic performance.
Methods: This was a retrospective cohort study; 191 patients booked for TAB during a five-year period were screened for inclusion. The study population was divided into two groups.
Giant cell arteritis and innovative treatments.
Curr Opin Allergy Clin Immunol
August 2023
Department of Medical Sciences and Public Health, University of Cagliari, Cagliari 09100, Italy.
Purpose Of Review: Giant cell arteritis (GCA) is an idiopathic and persistent condition characterized by granulomatous vasculitis of the medium and large vessels with overlapping phenotypes, including conventional cranial arteritis and extra-cranial GCA, also known as large-vessel GCA. Vascular problems linked with large vessel involvement may partly be caused by delayed diagnosis, emphasizing the necessity of early detection and the fast beginning of appropriate therapy. Glucocorticoids are the cornerstone of treatment for GCA, but using them for an extended period has numerous, often severe, side effects.
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