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Alzheimers Dement
December 2024
University of Southern California, Los Angeles, CA, USA.
Background: The lack of knowledge about the onset and progression of dementia hampers its early diagnosis and possible treatment leading to severe condition like Alzheimer's disease. Technological advancement like new brain network modeling tools might provide insight into the disease progression but a broader view of the biochemical changes induced by dementia in an early and pre-symptomatic stage needs to be explored. Therefore, a multicentric longitudinal study was designed to quantify proteins molecules associated with cognitive impairment.
View Article and Find Full Text PDFInsulin resistance as a mediator in the association between nickel exposure and metabolic dysfunction-associated steatotic liver disease.
Diabetol Metab Syndr
January 2025
Department of Gastroenterology, Renmin Hospital of Wuhan University, Wuhan, China.
Background: The myriad implications of heavy metal pollution on human health have garnered substantial attention within the academic domain. Nevertheless, a notable research gap persists, as there is currently insufficient direct investigation elucidating the intricate interplay between nickel exposure and the risk of metabolic dysfunction-associated steatotic liver disease (MASLD).
Methods: The data utilized in this study was sourced from the National Health and Nutrition Examination Survey 2017-2020.
Altered Protein Kinase A-Dependent Phosphorylation of Cav1.2 in Left Ventricular Myocardium from Haploinsufficient Rat Hearts.
Int J Mol Sci
December 2024
Institute of Pharmacology and Clinical Pharmacy, Faculty of Pharmacy, Biochemical and Pharmacological Center (BPC) Marburg, University of Marburg, 35032 Marburg, Germany.
encodes the α1c subunit of the L-type Ca channel, Cav1.2. Ventricular myocytes from haploinsufficient () rats exhibited reduced expression of Cav1.
View Article and Find Full Text PDFFaecal Metabolome Profiles in Individuals Diagnosed with Hyperplastic Polyps and Conventional Adenomas.
Int J Mol Sci
December 2024
Department of Microbiology and Biochemistry of Dairy Products, Instituto de Productos Lácteos de Asturias, Consejo Superior de Investigaciones Científicas (IPLA-CSIC), 33011 Oviedo, Spain.
Colorectal cancer (CRC) development is a gradual process in which progressive histological alterations of the intestinal mucosa damage occur over years. This process can be influenced by modifiable external factors such as lifestyle and diet. Most CRC cases (>80%) originate from conventional adenomas through the adenomatous pathway and usually harbour dysplastic cells, whereas the serrated pathway is less frequent (<20% cases) and comprises hyperplastic polyps and other polyps containing dysplastic cells.
View Article and Find Full Text PDFImpact of Intraoperative Opioid Use and a Combined Anesthesia Regimen in Patients Undergoing Radical Prostatectomy for Prostate Cancer in a Single-Center Cohort.
J Clin Med
December 2024
Department of Urology, University Hospital of the LMU Munich, 81377 Munich, Germany.
Higher intraoperative opioid doses may be associated with worse long-term oncological outcomes after radical prostatectomy (RP) for prostate cancer. We aimed to evaluate the impact of higher doses of intraoperative opioids and type of anesthesia on biochemical recurrence (BCR) and mortality after RP in a high-volume tertiary center. All patients underwent RP at our center between 2015 and 2021.
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