We report the palladium-catalyzed enantioselective cyclization of 1,6-enamidynes to form spirocyclic ring systems. We applied this methodology to the concise synthesis of the skeletal core of the kopsifoline alkaloids.
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| http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3678774 | PMC |
| http://dx.doi.org/10.1016/j.tet.2013.02.091 | DOI Listing |
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