The paper presents a comparative experimental study of flexion-extension movement in normal and osteoarthritic human knee. Measurements were performed on a group of seven healthy subjects and on a group of five patients with OA knees, for which experimental data were acquired for walking cycles on treadmill. Using an electrogoniometer-based acquisition system, the data were collected during the experimental gait on a treadmill with the speed equal to 3.6 km/h. The flexion angle during the gait cycle revealed differences with respect to flexion magnitude between the OA patients and the healthy subjects group. Statistical analysis demonstrated that the knee flexion angles were significantly different for experimental measurements of the OA patients' knees and healthy knees, but, also, the healthy knees of the patients were on average less flexed than gait cycle of the healthy subjects.
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Genet Test Mol Biomarkers
December 2024
SRM Dental College, Bharathi Salai, Chennai, India.
Periodontal disease worsens glycemic control due to the bidirectional link between periodontitis and type 2 diabetes mellitus (T2DM), involving inflammatory markers such as soluble tumor necrosis factor-like weak inducer of apoptosis (sTWEAK), tumor necrosis factor-α (TNF-α), and omentin-1. However, their combined role in T2DM with periodontitis has not been studied. This study aimed to evaluate the levels of these biomarkers in periodontitis patients with T2DM before and after nonsurgical periodontal therapy (NSPT).
View Article and Find Full Text PDFParasitol Res
December 2024
Department of Clinical Laboratory Sciences, School of Health Professions, Medical Branch, University of Texas, 301 University Blvd, Galveston, TX, 77555-0128, USA.
Naegleria fowleri is a free-living amoeba and the causative agent of Primary Amebic Meningoencephalitis (PAM), a rare yet almost always fatal disease that primarily affects children. While only 431 PAM cases have been reported worldwide, the southern states of the United States, including Texas, report the highest number of cases. Despite the high mortality of the disease, studies have identified antibodies to N.
View Article and Find Full Text PDFMAGMA
December 2024
Department of Radiology and Medical Informatics, Faculty of Medicine, University of Geneva, Geneva, Switzerland.
Objectives: Phosphorus-31 magnetic resonance spectroscopic imaging (P-MRSI) is a non-invasive tool for assessing cellular high-energy metabolism in-vivo. However, its acquisition suffers from a low sensitivity, which necessitates large voxel sizes or multiple averages to achieve an acceptable signal-to-noise ratio (SNR), resulting in long scan times.
Materials And Methods: To overcome these limitations, we propose an acquisition and reconstruction scheme for FID-MRSI sequences.
NeuroSci
November 2024
National Institute of Neurological Disorders and Strokes, National Institutes of Health, Bethesda, MD 20892, USA.
Classification of disease and healthy volunteer cohorts provides a useful clinical alternative to traditional group statistics due to individualized, personalized predictions. Classifiers for neurodegenerative disease can be trained on structural MRI morphometry, but require large multi-scanner datasets, introducing confounding batch effects. We test ComBat, a common harmonization model, in an example application to classify subjects with Parkinson's disease from healthy volunteers and identify common pitfalls, including data leakage.
View Article and Find Full Text PDFNurs Rep
December 2024
Department of Nursing, University of Valencia, 46010 Valencia, Spain.
Background: Loneliness can occur at any age, but it is more prevalent among older adults due to the associated risk factors. Various interventions exist to improve this situation, but little is known about their long-term effects. Our aims were to determine if these interventions have long-lasting effects and for how long they can be sustained.
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