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Genome-wide profiling of human cap-independent translation-enhancing elements. | LitMetric

We report an in vitro selection strategy to identify RNA sequences that mediate cap-independent initiation of translation. This method entails mRNA display of trillions of genomic fragments, selection for initiation of translation and high-throughput deep sequencing. We identified >12,000 translation-enhancing elements (TEEs) in the human genome, generated a high-resolution map of human TEE-bearing regions (TBRs), and validated the function of a subset of sequences in vitro and in cultured cells.

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Source
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3731418PMC
http://dx.doi.org/10.1038/nmeth.2522DOI Listing

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