Introduction: Patients with air-bone-gaps that cannot be corrected successfully by tympanoplasty or with mixed hearing loss may be treated with bone conducting hearing aids. Their disadvantages are the obvious external fixation components or the biological and psychosocial problems of open implants. We have developed a new partially implantable Bone Conduction Hearing Device (BCHD) without a percutaneous abutment and have been using them clinically for over 6 years. The principle of these BCHD is a magnetic coupling and acoustic transmission between implanted and external magnets. The goal of this study was to evaluate its clinical and audiologic results in patients with unilateral or bilateral congenital aural atresia.
Methods: Magnets are implanted into shallow bone beds in a 1-step procedure. The skin above the magnets is slightly thinned. The external device fixed with counter magnets in a base plate.
Patients: Twenty-one patients who have been implanted due to congenital atresia showed up for this follow-up study. The follow-up period was 19.3 ± 12.2 months, with a range of 0.2 to 46.6 months. The average age of the patients at the time of implantation was 12.4 years with a wide range from 6.0 to 50.0 years.
Results: The average hearing gain was 31 ± 8 dB, and the suprathreshold word recognition tests increased by 57% ± 23%. Strength of the magnetic force that the patients had chosen themselves measured 0.9 ± 0.4 N with a range from 0.3 to 1.8 N. Skin thickness over the implants measured sonographically was 3.9 ± 0.8 mm (range, 2.5-5.6 mm).
Discussion: This new bone conducting hearing device only needs one operation, has a very low risk for complication, and a hearing gain similar to other bone conducting hearing aids. We have found high comfort and safety of this system and conclude that it could be a valuable alternative to other conventional or percutaneous bone conducting hearing solutions.
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http://dx.doi.org/10.1097/MAO.0b013e31828682e5 | DOI Listing |
Sao Paulo Med J
January 2025
Associate Professor, Department of Nephrology, Ankara Bilkent City Hospital, Ankara, Turkey.
Background: Insulin resistance often occurs in patients with chronic kidney disease (CKD) owing to mineral and bone metabolism disorders. Fibroblast growth factor (FGF)-23 and soluble klotho (s-KL) play crucial roles in linking CKD with mineral and bone metabolism.
Objective: This study aimed to examine the relationship between insulin resistance and FGF-23 and s-KL in patients with non-diabetic pre-dialysis patients with CKD.
Codas
January 2025
Instituto de Psicologia, Serviço Social, Saúde e Comunicação Humana, Universidade Federal do Rio Grande do Sul - UFRGS - Porto Alegre (RS), Brasil.
Purpose: To ascertain whether Rapid Maxillary Expansion (RME) elicits effects on the functioning of the middle ear and air-bone gaps in children and adolescents.
Methods: Single-arm clinical trial, with data collection at four time points: before initiating Rapid Maxillary Expansion (RME) (T0), upon completion of RME (T1), three months post-RME completion (T2), and six months post-RME procedure (T3). The audiological assessment, conducted at all four time points, comprised otoscopy, pure tone and speech audiometry, tympanometry, and acoustic reflex investigation.
Br J Radiol
January 2025
2nd Department of Radiology, University General Hospital "ATTIKON", Medical School, National and Kapodistrian University of Athens, Greece.
In a rapidly evolving healthcare environment, artificial intelligence (AI) is transforming diagnostic techniques and personalised medicine. This is also seen in osseous biopsies. AI applications in radiomics, histopathology, predictive modelling, biopsy navigation, and interdisciplinary communication are reshaping how bone biopsies are conducted and interpreted.
View Article and Find Full Text PDFJ Mol Histol
January 2025
Department of Anatomy and Cell Biology, School of Medicine, Mashhad University of Medical Sciences, Mashhad, Iran.
Tumor necrosis factor-α (TNF-α) induces a multitude of actions and consequences in bone and cartilage resorption and immune response augmentation. In this research, we aimed to investigate the effects of TNF-α on osteogenesis parameters in newborn mice. Experimental research was conducted on 42 pregnant mice, dividing into seven groups as follows: control (no injection), vehicle 1 (PBS injection on 7-9th pregnancy days (PD)), vehicle 2 (PBS injection during pregnancy), experimental 1 (injection of 10 ng/kg of TNF-α on 7-9th PD), experimental 2 (injection of 100 ng/kg of TNF-α on 7-9th PD), experimental 3 (injection of 10 ng/kg of TNF-α during pregnancy) and experimental 4 (injection of 100 ng/kg of TNF-α during pregnancy).
View Article and Find Full Text PDFPhysiol Rep
February 2025
Motion and Exercise Science, University of Stuttgart, Stuttgart, Germany.
The maintenance of an appropriate ratio of body fat to muscle mass is essential for the preservation of health and performance, as excessive body fat is associated with an increased risk of various diseases. Accurate body composition assessment requires precise segmentation of structures. In this study we developed a novel automatic machine learning approach for volumetric segmentation and quantitative assessment of MRI volumes and investigated the efficacy of using a machine learning algorithm to assess muscle, subcutaneous adipose tissue (SAT), and bone volume of the thigh before and after a strength training.
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