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Cannabinoid-based Pharmacology for the Management of Substance Use Disorders.
Curr Top Behav Neurosci
January 2025
Department of Neurobiology, University of Maryland, School of Medicine, Baltimore, MD, USA.
In the last two decades, the endocannabinoid system has emerged as a crucial modulator of motivation and emotional processing. Due to its widespread neuroanatomical distribution and characteristic retrograde signaling nature, cannabinoid type I receptors and their endogenous ligands finely orchestrate somatic and axon terminal activity of dopamine neurons. Owing to these unique features, this signaling system is a promising pharmacological target to ameliorate dopamine-mediated drug-seeking behaviors while circumventing the adverse side effects of, for instance, dopaminergic antagonists.
View Article and Find Full Text PDFUntargeted Metabolic Phenotyping by LC-MS.
Methods Mol Biol
January 2025
Division of Systems Medicine, Department of Metabolism, Digestion and Reproduction, Imperial College, London, UK.
Untargeted analysis by LC-MS is a valuable tool for metabolic profiling (metabonomics/metabolomics), and applications of this technology have grown rapidly over the past decade. LC-MS offers advantages of speed, sensitivity, relative ease of sample preparation, and large dynamic range compared to other platforms in this role. However, like any analytical approach, there are still drawbacks and challenges that have to be overcome, some of which are being addressed by advances in both column chemistries and instrumentation.
View Article and Find Full Text PDFCAR-T therapy toxicities: the importance of macrophages in their development and possible targets for their management.
Discov Oncol
January 2025
Internal Medicine Department, Division of Hematology-Oncology, Loyola University Medical Center, 2160 S 1St Ave, Maywood, IL, 60153, USA.
CAR-T cell therapies have risen to prominence over the last decade, and their indications are increasing with several products approved as early as second line in Large B Cell non-Hodgkin Lymphomas. Their major toxicities are the cytokine release syndrome (CRS) and the Immune-effector Cell Associated Neurotoxicity Syndrome (ICANS). These entities involve a hyperinflammatory cascade which is amplified through the mononuclear phagocytic system (MPS).
View Article and Find Full Text PDF[The concept of health literacy in transition].
Bundesgesundheitsblatt Gesundheitsforschung Gesundheitsschutz
January 2025
Careum Stiftung, Zentrum für Gesundheitskompetenz, Pestalozzistrasse 3, 8032, Zürich, Schweiz.
Health literacy is a central resource for health-related decisions. Since the 1970s, however, the understanding of this term has changed in several ways. Initially, health literacy was considered only from the point of view of individual competencies, but in recent decades it has evolved into a more contextual understanding.
View Article and Find Full Text PDFEstablishing Decisional Cutoff Values of Neurofilament Light Chains in Cerebrospinal Fluid Measured by Fully Automated Chemiluminescent Enzyme Immunoassay.
J Clin Lab Anal
January 2025
Department of Biomedicine, Neurosciences and Advanced Diagnostics, Institute of Clinical Biochemistry, Clinical Molecular Medicine, and Clinical Laboratory Medicine, University of Palermo, Palermo, Italy.
Introduction: Neurofilament light chain (NfL) is one of the most important biomarkers in the field of clinical neurochemistry. Several analytical methods have been developed in the last decade. Recently, Fujirebio introduced a ready-to-use assay kit for measuring NfL levels in the cerebrospinal fluid (CSF) on the fully automated LUMIPULSE G System.
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