A series of zwitterionic spirocyclic compounds were synthesised. In vitro data revealed that these compounds were potent CCR1 antagonists. In particular, 2, 4, 11 and 20 inhibited CCR1 mediated chemotaxis of THP-1 cells in a functional assay.
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| http://dx.doi.org/10.1016/j.bmcl.2013.05.087 | DOI Listing |
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