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| http://dx.doi.org/10.1021/cr300463y | DOI Listing |
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Basic Science and Pathogenesis.
Alzheimers Dement
December 2024
Penn Neurodegeneration Genomics Center, Department of Pathology and Laboratory Medicine, University of Pennsylvania Perelman School of Medicine, Philadelphia, PA, USA.
Article Synopsis
- The Alzheimer's Disease Sequencing Project (ADSP) aims to advance precision medicine by sequencing and analyzing 150,000 genomes to better understand the genetic factors of Alzheimer's disease.
- The project emphasizes inclusivity by focusing on diverse populations and ensuring phenotypic data harmonization for more accurate comparisons.
- ADSP also presents significant opportunities for AI/ML researchers to utilize the data for predictive modeling, identifying biomarkers, and developing new therapies.
Volumetric Additive Manufacturing for Cell Printing: Bridging Industry Adaptation and Regulatory Frontiers.
ACS Biomater Sci Eng
January 2025
Manipal Centre for Biotherapeutics Research, Manipal Academy of Higher Education, Manipal, 576104 Karnataka, India.
Volumetric additive manufacturing (VAM) is revolutionizing the field of cell printing by enabling the rapid creation of complex three-dimensional cellular structures that mimic natural tissues. This paper explores the advantages and limitations of various VAM techniques, such as holographic lithography, digital light processing, and volumetric projection, while addressing their suitability across diverse industrial applications. Despite the significant potential of VAM, challenges related to regulatory compliance and scalability persist, particularly in the context of bioprinted tissues.
View Article and Find Full Text PDFCharacterization of global research trends and prospects on celastrol, a principal bioactive ingredient of Hook F: bibliometric analysis.
Pharm Biol
December 2025
Shanghai Health Commission Key Lab of Artificial Intelligence (AI)-Based Management of Inflammation and Chronic Diseases, Department of Central Laboratory, Gongli Hospital of Shanghai Pudong New Area, Shanghai, China.
Context: Celastrol, acknowledged as a prominent exemplar of the potential for transforming traditional medicinal compounds into contemporary pharmaceuticals, has garnered considerable attention owing to its extensive pharmacological activities. The increasing volume of publications concerning celastrol highlights its importance in current scientific inquiry. Despite the growing interest in this compound, a bibliometric analysis focused on this subject remains to be undertaken.
View Article and Find Full Text PDFSalivary pH, but not conductivity, is an indicator of diarrhea in neonatal calves.
Front Vet Sci
December 2024
Scotland's Rural College (SRUC), Edinburgh, United Kingdom.
Article Synopsis
- Neonatal calf diarrhea frequently leads to dehydration and metabolic acidosis, impacting calf mortality, growth, and productivity, prompting interest in technological disease detection.
- The study explored the relationship between saliva conductivity and pH with clinical and biochemical indicators in calves, assessing the health of 141 dairy-bred calves from one week old until 25 days or until they developed diarrhea.
- Results indicated that while saliva pH decreased in calves with diarrhea, saliva conductivity showed no correlation with diarrhea or dehydration, highlighting the complexity of hydration status assessments in these animals.
Outpatient group therapy for post-COVID patients - a naturalistic feasibility study of a face-to-face and online group concept.
Front Psychiatry
December 2024
Department of General Internal Medicine and Psychosomatics, Heidelberg University, Heidelberg, Germany.
Background: A significant number of individuals diagnosed with SARS-CoV-2 continue to suffer from persistent symptoms, a condition commonly referred to as Post-COVID syndrome (PCS). The most common manifestations are fatigue, post-exertional malaise, respiratory problems and cognitive deficits due to the lack of a causal treatment, therapeutic options remain symptom oriented. The aim of this study was to develop a low-threshold group therapy concept for patients with PCS and to test its feasibility in face-to-face and online format.
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