Two simple, accurate, and rapid methods were developed for simultaneous determination of sitagliptin phosphate and metformin hydrochloride in their pharmaceutical formulation. The first is a TLC method coupled with densitometry. The second is an HPLC method using a C18 column. The selectivity of the proposed methods was checked using laboratory-prepared mixtures. The proposed methods were successfully applied to the analysis of sitagliptin phosphate and metformin hydrochloride in bulk form and in their pharmaceutical formulation without interference from other additives.
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