Using microscopic techniques we have fabricated interstitial hyperthermia applicators having diameters of 0.20, 0.33 and 0.58 mm, which will fit through catheters of 30, 26 and 22 gauge, respectively. Existing commercial applicators having a diameter of 1.1 mm required 17 gauge (or larger) catheters. Our new applicators, which operate at 915 MHz, are a smaller version of a design used by others. We have characterized our applicators by determining the energy deposition patterns (SAR) in muscle-simulating phantoms. These patterns were determined by measuring the electric field intensity using a miniature implantable isotropic probe having a diameter of 3 mm. Contours of the SAR data for our applicators, as well as a larger commercial applicator, show that all of these applicators exhibit similar heating patterns. Test results suggest that the durability and power handling capability of our submillimetre applicators are adequate for use in patients. Our new applicators should be useful in the percutaneous treatment of deep-seated tumours, intraoperative treatments, and also permit intraluminal or intravascular access to tumours.
Download full-text PDF |
Source |
|---|---|
| http://dx.doi.org/10.3109/02656739009140966 | DOI Listing |
Publication Analysis
Top Keywords
Similar Publications
Safety and Efficacy of Incorporating Actellic 300 CS into Soil Wall Plaster for Control of Malaria Vectors in Rural Northeastern Uganda.
Trop Med Infect Dis
December 2024
Med Biotech Laboratories, Kampala P.O. Box 9364, Uganda.
Indoor residual spraying (IRS) and the use of insecticide-treated bednets for malaria vector control have contributed substantially to a reduction in malaria disease burden. However, these control tools have important shortcomings including being donor-dependent, expensive, and often failing because of insufficient uptake. We assessed the safety and efficacy of a user-friendly, locally tailored malaria vector control approach dubbed "Hut Decoration for Malaria Control" (HD4MC) based on the incorporation of a WHO-approved insecticide, Actellic 300 CS, into a customary hut decoration practice in rural Uganda where millions of the most vulnerable and malaria-prone populations live in mud-walled huts.
View Article and Find Full Text PDFTransmission-Based Monitoring of Dual-Applicator Microwave Ablation Discriminates Discontiguous from Contiguous Ablation Zones in an In Vivo Porcine Liver Model.
J Vasc Interv Radiol
January 2025
Department of Electrical and Computer Engineering, Kansas State University, Manhattan, KS 66506, USA; Department of Biomedical Engineering, The George Washington University, Washington, DC 20052, USA. Electronic address:
Purpose: To determine the technical feasibility of discriminating discontiguous from contiguous ablation zones between a pair of microwave ablation (MWA) applicators using broadband microwave transmission signal measurements in an in vivo porcine liver model.
Methods: Dual applicator 2.45GHz MWA was performed using one directional and one omnidirectional applicator, spaced 3cm apart, under imaging guidance.
Computational Design of a Thermal Applicator for Brain Hyperthermia Controlled by Capacitor Positioning in Loop Coils.
Magn Reson Med Sci
January 2025
Department of Biomedical Engineering, Gachon University, Seongnam, Gyeonggi, Korea.
Purpose: Hyperthermia is a treatment that applies heat to damage or kill cancer cells and can be also used for drug deliveries. It is important to apply the heat into the specific area in order to target the cancer tissue and avoid damaging healthy tissue. For this reason, the development of heat applicators that have the capability to deliver the heat to the target area is vital.
View Article and Find Full Text PDFDosimetry of Continuous Random Motion in High Dose Rate Strontium-90 Plesiotherapy.
Vet Radiol Ultrasound
January 2025
Department of Veterinary Medicine and Surgery, University of Missouri, Columbia, Missouri, USA.
Strontium-90 plesiotherapy delivers high doses of radiation to superficial lesions (<3 mm depth) with excellent sparing of deeper tissues. The sealed-source applicator tip is circular and 8-10 mm in diameter. Larger treatment fields are treated with multiple overlapping fields.
View Article and Find Full Text PDFDevelopment of a Paper-Based Disposal Thin-Film Solid-Phase Microextraction Tool for the Quantification of Environmentally Hazardous 4-Chlorophenol in Water.
ACS Omega
January 2025
Department of Biotechnology, Manipal Institute of Technology, Manipal Academy of Higher Education, Manipal, Karnataka 576104, India.
The presence of chlorinated compounds in water resources presents various environmental and health risks. Therefore, there is a precise need to develop a potential technique for fast and efficient monitoring of chlorinated contaminants in water due to environmental protection and regulation compliance. Here, we designed a paper-based thin-film solid-phase microextraction (TF-SPME) patch to estimate 4-chlorophenol (4-CRP), a widely known environmentally hazardous pollutant in water samples.
View Article and Find Full Text PDFWant AI Summaries of new PubMed Abstracts delivered to your In-box?
Enter search terms and have AI summaries delivered each week - change queries or unsubscribe any time!