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Background: Type 2 diabetes mellitus (T2DM) is among the modifiable risk factors for Alzheimer's disease (AD) and ranks among the leading chronic diseases globally. It is characterized by elevated blood glucose levels and insulin resistance, which over time may impair memory performance. More so, saliva appears to be a promising biomarker for the diagnosis of AD since conventional methods appear invasive and expensive in the country.
View Article and Find Full Text PDFBackground: Mild cognitive impairment (MCI) is largely under-diagnosed by primary care physicians. There is an urgent need to develop new objective screening tools to assist with early detection of MCI. Time-domain functional near-infrared spectroscopy (TD-fNIRS) can be used to measure brain function in clinical settings and may fill this need.
View Article and Find Full Text PDFBiomarkers.
Alzheimers Dement
December 2024
Texas Tech University Health Sciences Center, Lubbock, TX, USA.
Background: Diabetes, a chronic metabolic disease leading to damage to multiple organs and the nervous system, is associated with cognitive decline. Moreover, Vitamin D (VD) insufficiency/deficiency is implicated as a risk factor for diabetes. However, the specifics of the relationships between these variables remain unclear.
View Article and Find Full Text PDFDeveloping Topics.
Alzheimers Dement
December 2024
Hurvitz Brain Sciences Program, Sunnybrook Research Institute, Toronto, ON, Canada.
Background: 20-hydroxyeicosatetranoic acid (20-HETE) is a potent vasoconstrictor synthesized by the CYP4F2 enzyme. The CYP4F2 missense variant rs3093105 A>C (W12G) has been implicated in hypertension and stroke, risk factors for Alzheimer's disease (AD), and with decreased 20-HETE activity. To explore the potential role of the CYP4F2/20-HETE pathway and AD, this study investigated associations between the rs3093105 variant and AD phenotypes.
View Article and Find Full Text PDFTryptophan metabolism-related gene CYP1B1 serves as a shared biomarker for both Parkinson's disease and insomnia.
Sci Rep
January 2025
Department of Neurology, The First Affiliated Hospital of Zhengzhou University, No.1 Jianshe Dong Road, Zhengzhou, Henan, China.
Parkinson's disease (PD) and insomnia are prevalent neurological disorders, with emerging evidence implicating tryptophan (TRP) metabolism in their pathogenesis. However, the precise mechanisms by which TRP metabolism contributes to these conditions remain insufficiently elucidated. This study explores shared tryptophan metabolism-related genes (TMRGs) and molecular mechanisms underlying PD and insomnia, aiming to provide insights into their shared pathogenesis.
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