AI Article Synopsis
- tEMD (tunneling endoscopic muscularis dissection) was tested on 12 patients with subepithelial tumors in the esophagus and gastric cardia, aiming to assess its clinical feasibility and safety.
- All tumors were successfully resected, with 100% en bloc resection rates, and no major complications like delayed hemorrhage or chronic fistulas were reported during follow-up.
- The findings suggest that tEMD is a promising minimally invasive option for treating these tumors, as no recurrence was observed in patients after an average follow-up of about 7 months.
Article Abstract
Background And Aims: Endoscopic resection of esophageal or cardial subepithelial tumors (SETs) originating from the muscularis propria (MP) is rarely done due to the high risk of perforation, fistula formation, and secondary infection. The aim of this study was to evaluate the preliminary clinical feasibility and safety of tunneling endoscopic muscularis dissection (tEMD) for resection of SETs located in the esophagus and gastric cardia
Methods: Twelve patients with SETs originating from the MP of the esophagus (n = 7) or cardia (n = 5) were treated by tEMD. The procedure included creation of a submucosal tunnel to reach the tumor, dissection of the tumor from the surrounding submucosal tissue and the unaffected MP layer, full-thickness resection of the tumor and affected MP, and subsequent closure of the tunnel mucosal entry with endoscopic clips.
Results: The en bloc resection rate was 100 % (seven lesions affected the deep MP so complete MP resection was performed; five lesions affected the superficial MP for a partial MP resection). The average tumor size was 18.5 ± 6.9 (range 10-30) mm. The mean operating time was 78.3 ± 25.5 (range 50-130) min. The histological diagnoses were two gastrointestinal stromal tumors with very low risk, nine leiomyomas, and one schwannoma. Air leakage and effusion included subcutaneous and mediastinal emphysema in eight patients (66.7 %), pneumothorax in four (33.3 %), pneumoperitoneum in three (25.0 %), and small pleural effusion in two (16.7 %). All air leakage and effusion cases were resolved with conservative management. No patient developed delayed hemorrhage and chronic fistula after tEMD. During the mean follow-up time of 7.1 ± 4.3 (range 2-15) months, no tumor recurrence was found in any patient.
Conclusions: tEMD appears to be a feasible minimally invasive and effective treatment for patients with SETs originating from the MP layer of the esophagus and cardia.
Download full-text PDF |
Source |
|---|---|
| http://dx.doi.org/10.1007/s00464-013-3023-3 | DOI Listing |
Publication Analysis
Top Keywords
Similar Publications
Molecular diversity of embryonic-type neuroectodermal tumors arising from testicular germ cell tumors.
Mod Pathol
December 2024
Department of Pathology & Laboratory Medicine, University of California Los Angeles,. Electronic address:
Embryonic-type neuroectodermal tumors (ENTs) arising from testicular germ cell tumors (GCTs) is a relatively common type of somatic transformation in GCTs with poor prognosis and limited therapeutic options, particularly when patients develop disease recurrence or metastasis. Knowledge of key events driving this transformation is limited to the paucity of comprehensive genomic data. We performed a retrospective database search in a CLIA- and CAP-certified laboratory for testicular GCT-derived ENTs that had previously undergone NGS-based comprehensive genomic profiling during the course of clinical care.
View Article and Find Full Text PDFSharing of alleles between and associated with extensive drug resistance in isolates from infants and poultry in the Peruvian Amazon.
mBio
December 2024
Division of Infectious Diseases and International Health, School of Medicine, University of Virginia, Charlottsville, Virginia, USA.
is a serious health threat because of the rapid progressive evolution of antimicrobial resistance and efficient transmission from zoonotic as well as human sources. Resistance to fluoroquinolones and macrolides is particularly concerning as this compromises the two most effective oral antibiotic agents currently available for human campylobacteriosis. Here, we report on the prevalence and worldwide distribution of the operon , which encodes an efflux pump conferring high levels of combined resistance to fluoroquinolones and macrolides in strains isolated from poultry ( = 75) and children ( = 177).
View Article and Find Full Text PDFTowards interactive AI-authoring with prototypical few-shot classifiers in histopathology.
J Pathol Inform
December 2024
Fraunhofer IIS, Fraunhofer Institute for Integrated Circuits IIS, Medical Image Analysis Group, Erlangen, Germany.
A vast multitude of tasks in histopathology could potentially benefit from the support of artificial intelligence (AI). Many examples have been shown in the literature and first commercial products with FDA or CE-IVDR clearance are available. However, two key challenges remain: (1) a scarcity of thoroughly annotated images, respectively the laboriousness of this task, and (2) the creation of robust models that can cope with the data heterogeneity in the field (domain generalization).
View Article and Find Full Text PDFObservation of quantum oscillations near the Mott-Ioffe-Regel limit in CaAs.
Natl Sci Rev
December 2024
State Key Laboratory of Surface Physics and Institute for Nanoelectronic Devices and Quantum Computing, Fudan University, Shanghai 200433, China.
The Mott-Ioffe-Regel limit sets the lower bound of the carrier mean free path for coherent quasiparticle transport. Metallicity beyond this limit is of great interest because it is often closely related to quantum criticality and unconventional superconductivity. Progress along this direction mainly focuses on the strange-metal behaviors originating from the evolution of the quasiparticle scattering rate, such as linear-in-temperature resistivity, while the quasiparticle coherence phenomena in this regime are much less explored due to the short mean free path at the diffusive bound.
View Article and Find Full Text PDFGeneralized fractional optimization-based explainable lightweight CNN model for malaria disease classification.
Comput Biol Med
December 2024
Future Technology Research Center, National Yunlin University of Science and Technology, 123 University Road, Section 3, Douliou, Yunlin, 64002, Taiwan. Electronic address:
Over the past few decades, machine learning and deep learning (DL) have incredibly influenced a broader range of scientific disciplines. DL-based strategies have displayed superior performance in image processing compared to conventional standard methods, especially in healthcare settings. Among the biggest threats to global public health is the fast spread of malaria.
View Article and Find Full Text PDFWant AI Summaries of new PubMed Abstracts delivered to your In-box?
Enter search terms and have AI summaries delivered each week - change queries or unsubscribe any time!