Download full-text PDF |
Source |
|---|
Publication Analysis
Top Keywords
Similar Publications
Trends in utilization of tramadol and other opioids in Denmark 2017-2023: A nationwide drug utilization study.
Br J Clin Pharmacol
January 2025
Department of Clinical Pharmacology, Copenhagen University Hospital Bispebjerg and Frederiksberg, Copenhagen, Denmark.
The use of tramadol and other opioids for pain management has been accompanied by a multitude of challenges and concerns worldwide. The use of tramadol saw a decline in Denmark during 2017-2019 accompanied by a slight increase in the use of morphine and oxycodone. Using the Danish National Prescription Registry and utilizing data until and including 2023, we aimed to provide updated data on the utilization patterns of tramadol and other opioids in Denmark.
View Article and Find Full Text PDFUse of Causal Framework to Evaluate Effect of Abuse Deterrent Properties of Extended-Release Oxycodone on Tampering in a Real-World Settings.
Pharmacoepidemiol Drug Saf
January 2025
Rocky Mountain Poison & Drug Safety, Denver Health & Hospital Authority, Denver, Colorado, USA.
Purpose: To assess whether exposure to an extended-release (ER) oxycodone with abuse deterrent properties (ADF) reduced tampering of oxycodone in a real-world, postmarket setting to address the thinking behind Category 4 labeling by the FDA.
Methods: Data from an observational cross-sectional study of the general adult population (2022) was used under a causal framework to estimate the confounding-adjusted odds of tampering oxycodone after exposure to two types of ADF ER oxycodone. The tampering behaviors of those who used only single entity immediate-release (SE-IR) oxycodone was used as a comparison.
Oxymorphone and Oxycodone Pharmacy Purchases in US Counties: Prelude to the Largest Rural Human Immunodeficiency Virus Outbreak in US History.
Pharmacoepidemiol Drug Saf
December 2024
Department of Behavioral Science, College of Medicine, University of Kentucky, Lexington, Kentucky, USA.
Article Synopsis
- The study investigates the surge of HIV cases in Scott County, Indiana, linked to the misuse of Opana ER, an opioid medication that replaced OxyContin due to its reformulation.
- It analyzes pharmacy transaction data from 2007 to 2019, showing that Opana ER usage in Scott County skyrocketed after OxyContin's formula changed and peaked just before the HIV outbreak in 2014.
- The findings suggest that the reformulation led to a significant drop in Opana ER transactions during the HIV outbreak, highlighting the importance of monitoring pharmaceutical sales to prevent drug misuse and related health crises.
The Role of Acid-Sensing Ion Channel 1A (ASIC1A) in the Behavioral and Synaptic Effects of Oxycodone and Other Opioids.
Int J Mol Sci
October 2024
Department of Psychiatry, University of Iowa, Iowa City, IA 52242, USA.
Opioid-seeking behaviors depend on glutamatergic plasticity in the nucleus accumbens core (NAcc). Here we investigated whether the behavioral and synaptic effects of opioids are influenced by acid-sensing ion channel 1A (ASIC1A). We tested the effects of ASIC1A on responses to several opioids and found that mice had elevated behavioral responses to acute opioid administration as well as opioid seeking behavior in conditioned place preference (CPP).
View Article and Find Full Text PDFDiabetes is a complex disease that impacts more than 500 million people across the world. Many of these individuals will develop diabetic neuropathy as a comorbidity, which is historically treated with exogenous opioids, such as morphine, oxycodone, or tramadol. Although these opioids are effective analgesics, growing evidence indicates that they may directly impact the endocrine pancreas function in patients.
View Article and Find Full Text PDFWant AI Summaries of new PubMed Abstracts delivered to your In-box?
Enter search terms and have AI summaries delivered each week - change queries or unsubscribe any time!