AI Article Synopsis
- Protein S100B has been identified as a potential biomarker for brain damage, particularly in conditions like subarachnoid hemorrhage (SAH), severe head injuries, and strokes, but this study found it did not predict cerebral vasospasm in SAH patients.
- The study involved 18 patients with SAH, collecting five samples of serum and cerebrospinal fluid (CSF) S100B levels over several days, but results showed no significant differences between those who developed vasospasm and those who did not.
- While some patients did show elevated S100B levels prior to vasospasm, the low number of subjects meant that no statistically significant conclusions could be drawn regarding S100B as a reliable predictor
Article Abstract
Background: Protein S100B has proven to be a useful biomarker for cerebral damages. Increased levels of serum and cerebrospinal fluid (CSF) S100B have been shown in patients suffering subarachnoid hemorrhage (SAH), severe head injury and stroke. In patients with SAH, the course of S100B levels has been correlated with neurological deficits and outcome. Cerebral vasospasm is a major contributor to morbidity and mortality. The primary aim of this study was to investigate the potential of S100B protein as a predictor of cerebral vasospasm in patients with severe SAH.
Materials And Methods: Patients with SAH, Fisher grade 3 and 4, were included in the study. Five samples of CSF and serum S100B were collected from each patient. The first sample (baseline sample) was drawn within the first 3 days following ictus and the following four samples, once a day on days 5-8, with day of ictus defined as day 1. Clinical suspicion of cerebral vasospasm confirmed by computed tomography angiography was used to diagnose cerebral vasospasm.
Results: A total of 18 patients were included. Five patients (28%) developed cerebral vasospasm, two (11%) developed ventriculitis. There were no significant differences between S100B for those with and without vasospasm. Serum S100B levels in patients with vasospasm were slightly lower within the first 5 days following ictus, compared to patients without vasospasm. Two out of five patients had elevated and increasing serum S100B prior to vasospasm. Only one showed a peak level of S100B 1 day before vasospasm could be diagnosed. Due to the low number of patients in the study, statistical significance could not be reached.
Conclusion: Neither serum nor CSF S100B can be used as predictor of cerebral vasospasm in patients suffering from SAH.
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| http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3674401 | PMC |
| http://dx.doi.org/10.3389/fneur.2013.00065 | DOI Listing |
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