Squamous cell carcinoma (SCC) is a malignant tumour arising from the keratinising cells of the epidermis. It is slow growing, locally invasive and has the potential to metastasise to other organs of the body. We report an unusual presentation of a rapidly enlarging, well-differentiated SCC on the upper lip of a 75-year-old woman. Rapidly enlarging skin lesions in specialised areas pose great challenges in its management. As the lesions increase in size, they eliminate first-line reconstructive options that can compromise functional and aesthetic outcomes. Accurate histological diagnosis prior to surgery is paramount, as it bears significance to the excision margins. Early, urgent referral to a specialist unit is essential and may avoid the need for more invasive procedures and associated morbidity.
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http://dx.doi.org/10.1136/bcr-2013-009524 | DOI Listing |
Ann Thorac Surg Short Rep
December 2024
Liaison Healthcare Engineering Section, Kochi Medical School, Kochi, Japan.
Int J Surg Case Rep
January 2025
Poostchi Ophthalmology Research Center, Department of Ophthalmology, School of Medicine, Shiraz University of Medical Sciences, Shiraz, Iran. Electronic address:
Introduction And Importance: Conjunctival squamous cell carcinoma (SCC) is the most advanced form of ocular surface squamous neoplasia (OSSN), with varying incidence rates influenced by factors such as age, UV exposure, and occupation. Early detection is crucial, but misdiagnosis is common, especially when SCC mimics benign conditions like pterygium.
Case Presentation: An 83-year-old Caucasian male farmer presented with a rapidly enlarging nasal limbal lesion, initially misdiagnosed as pterygium.
J Craniofac Surg
January 2025
Division of Plastic Surgery, National Center for Child Health and Development.
Background: To analyze the serial changes in cranial asymmetry (CA) during helmet therapy for deformational plagiocephaly (DP).
Methods: The subjects were 159 patients with DP who visited National Center for Child Health and Development between October 2011 and March 2014 and completed helmet therapy. The authors retrospectively collected information from medical records and analyzed the rate of improvement of deformation.
Genes (Basel)
December 2024
Department of Ophthalmology, Eye Center, UC Davis School of Medicine, University of California Davis, Sacramento, CA 95817, USA.
Background/objective: The Rs1 exon-1-del rat (Rs1KO) XLRS model shows normal retinal development until postnatal day 12 (P12) when small cystic spaces start to form in the inner nuclear layer. These spaces enlarge rapidly, peak at P15, and then collapse by P19.
Methods: We explored the possible involvement of Kir4.
Glucose-6-Phosphatase (G6Pase), a key enzyme in gluconeogenesis and glycogenolysis in the mammalian liver and kidney, converts glucose-6-phosphate to glucose for maintaining systemic blood glucose homeostasis during nutrient deprivation. However, its function has remained elusive in insects, which have no need for G6Pase in sugar homeostasis since they convert glucose-6-phosphate to trehalose, their main circulating sugar, via trehalose phosphate synthase (TPS1). In this study we identify an unexpected and essential requirement for G6Pase in male fertility, specifically to produce motile sperm.
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