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In vivo dynamic tracking of cerebral chloride regulation using molecularly tailored liquid/liquid interfacial ultramicro iontronics.
Sci Adv
December 2024
Beijing National Laboratory for Molecular Sciences, College of Chemistry and Molecular Engineering, Peking University, Beijing 100871, China.
Article Synopsis
- Chloride ions play a crucial role in brain function and are linked to neurodegenerative diseases, but traditional methods for detecting them are ineffective due to their inactivity in electrochemical reactions.
- A new technique using specially designed liquid/liquid interfacial ultramicro iontronics (L/L-UIs) allows for the real-time sensing of these chloride ions in living organisms by utilizing unique ionophores in a gel.
- This method not only demonstrates the dynamic regulation of chloride ions in neurons influenced by GABA receptors but also opens up possibilities for tracking other important ions and molecules in the brain, aiding in research and treatment of various brain disorders.
Unraveling the socio-cognitive consequences of KCC2 disruption in zebrafish: implications for neurodevelopmental disorders and therapeutic interventions.
Front Mol Neurosci
October 2024
Department of Biology, York University, Toronto, ON, Canada.
During postnatal brain development, maintaining a delicate balance between excitation and inhibition (E/I) is essential for the precise formation of neuronal circuits. The K+/cl- cotransporter 2 (KCC2) is instrumental in this process, and its dysregulation is implicated in various neurological disorders. This study utilized zebrafish () to investigate the socio-cognitive consequences of KCC2 disruption.
View Article and Find Full Text PDFMidbrain KCC2 downregulation: Implications for stress-related and substance use behaviors.
Curr Opin Neurobiol
October 2024
Department of Pharmacology & Physiology, Interdisciplinary Program in Neuroscience, Georgetown University, Washington, DC 20057, USA. Electronic address:
Stress-related and substance use disorders are both characterized by disruptions in reward-related behaviors, and these disorders are often comorbid with one another. Recent investigations have identified a novel mechanism of inhibitory plasticity induced by both stress and substance use within the ventral tegmental area (VTA), a key region in reward processing. This mechanism involves the neuron-specific potassium chloride cotransporter isoform 2 (KCC2), which is essential in modulating inhibitory signaling through the regulation of intracellular chloride (Cl) in VTA GABA neurons.
View Article and Find Full Text PDFThe P2X7 Hypothesis of Central Post-Stroke Pain.
Int J Mol Sci
June 2024
Institute of Biomedical Sciences, Academia Sinica, Taipei 11529, Taiwan.
The present study examined how P2X7 receptor knockout (KO) modulates central post-stroke pain (CPSP) induced by lesions of the ventrobasal complex (VBC) of the thalamus in behaviors, molecular levels, and electrical recording tests. Following the experimental procedure, the wild-type and P2X7 receptor KO mice were injected with 10 mU/0.2 μL type IV collagenase in the VBC of the thalamus to induce an animal model of stroke-like thalamic hemorrhage.
View Article and Find Full Text PDFHypothalamic-Pituitary-Adrenal Axis Dysfunction Elevates SUDEP Risk in a Sex-Specific Manner.
eNeuro
July 2024
Tufts University School of Medicine, Boston, Massachusetts 02111
Epilepsy is often comorbid with psychiatric illnesses, including anxiety and depression. Despite the high incidence of psychiatric comorbidities in people with epilepsy, few studies address the underlying mechanisms. Stress can trigger epilepsy and depression.
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